Journal of the Korean Pediatric Society 1982;25(1):41-44.
Published online January 31, 1982.
A Clinical Trial of Polybutine Syrup to Pediatric G-I Symptomes.
Il Sin Moon, Kyung Sik Ro, Ik Jun Lee, Du Bong Lee
Department of Pediatrics, Catholic Medical College, Korea.
구토설사 환아에서의 Polybutine 현탁액 사용 경험
문일신, 노경식, 이악준, 이두봉
가톨릭의과대학 소아과학교실
This clinical trial was undertaken on 32 infants and chhildren who had G-I symptoms caused by a few diseases, such as meningitis, parenteral infection and intestinal infection. Out of 32 patients, six had vomiting only, caused by meingitis and habitual vomiting, eighteen had vomiting and diarrhea both which caused by parenteral infection and rest of them (8) had diarrhea only, caused by intestinal infection. Polybutine syrup, which 5.0 ml contain 24 mg of trimebutine, was given to these patients as follows; 2.5 ml twice a day at 6 months of age, 5.0 ml twice a day at 6 months to one year and 10 ml three times a day at 1-5 years of age. In ten of 24 patients, who had vomiting only (6), vomiting and diarrhea (18), the symptoms were improved within 48 hours, and rest of them (10) was also shown the improvement of their symptoms within 5 days after medication. In comparison of polybutine treated group and not treated group, the effectiveness of polybutine treatment for the symptoms was statistically meaningful.
Key Words: Polybutine, G-I symptomes

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