| Electron Microscopic Study of the Renal Proximal and Distal Convuluted Tubular Epithelial and Distal Convoluted Tubular Epithelial Cells after Administration of Aspirin. |
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Sung Gum Hong1, Cheul Woon Back1, Im Ju Kang1, Byung Heon Kim2, Dong Koo Lee2 |
1Department of Pediatrics, Fatima Hospital，Taegu, Korea
2Department of Pathology Graduate School, Kyungpook National Univesity Taegu，Korea |
| Aspirin 투여에 의한 신근위 및 원위곡뇨세관 상피세포의 미세형태학적 변화
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홍승근1, 백철운1, 강임주1, 김병헌2, 이동구2 |
1대구파티마병원 소아과
2경북대학교 의과대학 병리학교실 |
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| Abstract |
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The author has investigated ultrastructural changes of the renal proximal and distal convoluted tubular epithelial cells of rats with oral administration of aspirin, COmg per kg of body weight for 15 and 30 days consecutively.
The experimental animals have divided into two group. The group I was received aspirin for 15 consecutive days and group H for 30 days. The animals were sacrificed 30 minutes, 1 and 3 days after administration. Then both
kidney were removed and examined grossly, histologically and electron microscopically.
The results were summarized as follow: Electron microscopically the proximal convoluted tubular epithelial cells showed partial shedding of microvilli, moderate increase in number, and dilatation of SER, moderate loss of
mitochondial cristae, considerable thickening of basement membrane and moderate disappearance of irregularity of basal intussusception in experimental group I. In group H, The proximal epithelial cells were more severely injured than group I. subcellular morphologic changes according to intervals of sacrificed time after administration were similar. In the distal epithelial cells, destruction and disappearance of cytoplasmic organelles with nuclear pyknosis and prominent disappearance and irregular arrangement of basal intussusception were seen in both groups. As the above result, it suggested that injuries of the renal proximal convoluted epithelial
cells induced by aspirin occur mainly in SER, [mitochondria, basal intussception, microvilli, and basement membrane, and these changes are reversible,the distal epithelial cells showed necrotic processes in the cytoplasmic and nuclear elements which were irreversible changes.
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| Key Words:
Aspirin, Renal proximal and distal Convoluted tubular cells. |
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