Journal of the Korean Pediatric Society 1988;31(1):106-112.
Published online January 31, 1988.
6 Cases of Intracranial Hemorrhage due to late Late Hemorrhage Disease of Infancy.
Sang Ho Choi, Jae You Choi, Jee Sung Kim, Im Ju Kang
Department of Pediatrics, Fatima Hospital, Dae Gu, Korea
두개내 출혈을 동반한 영아기 출혈성 질환 6례
최상호, 최재유, 김지성, 강임주
대구 파티마병원 소아과
Received: 23 September 1987
A bleeding syndrome in early infancy due to vitamin K deficiency has been reported sporadically from various parts of world. The syndrome has similarities to hemorrhagic disease of newborn. The main differences are that it is found in an older age group, the pathogenesis is unknown, and intracranial hemorrhage are frequent with a resultant high mortality rate. We have experienced 6 cases of spontaneous intracranial hemorrhage in the absence of known trauma from 1 to 3 months of age. Coagulation studies showed marked prolongation of prothrombin time and partial thromboplastin time. Satisfactory clinical and laboratory results were demonstrated after vitamin K administration and fresh blood transfusion to correct the coagulation defect and anemia.
Key Words: Late hemorrhagic disease of infancy, Vitamin K deficiency, Intracranial hemorrhage

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