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Effect of Unilateral Pneumonectomy on the Compensatory Growing Pattern and the Function of the Type II Pneumocyte of the Contralateral Lung in Adult Rabbits.

Journal of the Korean Pediatric Society 1988;31(10):1315-1320.
Published online October 31, 1988.
Effect of Unilateral Pneumonectomy on the Compensatory Growing Pattern and the Function of the Type II Pneumocyte of the Contralateral Lung in Adult Rabbits.
Il Youl Ma1, Jeong Ok Hah1, Yong Man Lee2, Suck Kang Lee2
1Department of Pediatrics, College of Medicine, Yeoungnam University Taegu, Korea
2Department of Physiology, College of Medicine, Yeoungnam University Taegu, Korea
가토에 있어서 일측 폐장절제시 반대측 폐장의 핵산함량 및 제 2 형 폐포세포의 기능에 미치는 영향
마인열1, 하정옥1, 이영만2, 이석강2
1영남대학교 의과대학 소아과학교실
2영남대학교 의과대학 생리학교실
Received: 5 February 1988   • Accepted: 2 May 1988
Abstract
In order to confirm the effect of unilateral pneumonectomy on the compensatory growing pattern and the function of the type II pneumocyte in the contralateral lung, pneumonectomy was performed on the right lung of the New Zealand White rabbits. Five days after the surgery, pneumonectomized (PN) and control(CN) rabbits* lung were resected. As a result f the measurement of the left lung weight and body weight, L/B(lung weight/body weight) was calculated in PN and CN rabbits. By calaculating of the L/B, the compensatory growing of the PN rabbit left lung was confirmed. Determination of DNA-P and RNA-P content in the PN rabbit left lung revealed that DNA-P content did not changed while RNA-P content increased significantly (p<0.01) in comparison with DNA-P and RNA-P content of CN rabbit left lung. Therefore significant increase of RNA-P/DNA-P in PN rabbit left lung signified that the hypertrophy was a main cellular event during the compensatory lung growing. The fact that phospholipid-P content was increased in the pulmonary lavage fluid of the PN rabbit left lung suggested that as a result of the unilateral pneumonectomy, the hypertrophy of the type II pneumocytes occured by a certain humoral factor and which caused increased secretion of pulmonary surfactant.
Key Words: Pneumonectomy, Compensatory Growth


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