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A Study of Milk β-Glucuronidase Activity in Breast Milk Associating with Neonatal Jaundice.

Journal of the Korean Pediatric Society 1989;32(9):1202-1209.
Published online September 30, 1989.
A Study of Milk β-Glucuronidase Activity in Breast Milk Associating with Neonatal Jaundice.
Soo Chun Kim, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
신생아 모유성황달에서 모유내 β-Glucuronidase 활성도에 관한 연구
김수천, 배종우, 최용묵, 안창일
경희대학교 의과대학 소아과학교실
Received: 20 February 1989   • Accepted: 20 April 1989
Abstract
Since the 1960s, several reports have been presented to explain how the ingestion of human milk is related to neonatal jaundice. Recently, the jaundiced neonates whose mother’s milk contain sub- stances (eg, pregnane 3a, 20β-diol, lipoprotein lipase, free fatty acid, β-glucuronidase etc) facilitating the reabsorption of unconjugated bilirubin in the neonatal intestine through the enhancement of the enterohepatic circulation, were called the breast milk jaundice syndrome. To evaluate the relation between the effect of β-glucuronidase activity in maternal milk and the appearance of breast milk jaundice, this study were undertaken. The β-glucuronidase activity in breast milk was measured in 50 cases of breast milk jaundice group (study group) and 53 cases of normal control group along with serum bilirubin concentration in breast milk jaundice group. The results were as follows; 1) In breast milk jaundice group, the peak total bilirubin concentration was 15.0-19.9 mg/dl which was most common (20 cases, 40.0%). 2) In breast milk jaundice gorup, the appearance of peak serum bilirubin concentration was the age group of 7 to 13 days of life which was most common. 3) Average enzymatic activity of ^-glucuronidase was 10.64 ±6.76 n mole/ml in breast milk jaun- dice gorup, whereas it was 6.25 ±4.23 n mole/min/ml in control group. So this enzymatic activity in breast milk jaundice group is significantt, statistically (p< 0.001). 4) The relationship betweeen increase of total bilirubin concentration in neonates and increase of β-glucuronidase activity in maternal milk was not significant, statistically (p>0.05). Therefore, it is suggested that β-glucuronidase play a role of developing jaundice in breast milk jaundiced neonates.
Key Words: β-Glucuronidase, Breast milk jaundice, Hyperbilirubinemia of newborn


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