| Methylprednisolone Pulse Therapy in Childhood Nephropathies. |
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Moon A Kim, Pyung Kil Kim |
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Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea |
| 소아 신질환 환아에서 Pulse Therapy의 치료 효과 |
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김문아, 김병길 |
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연세대학교 의과대학 소아과학교실 |
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Received: 25 January 1989 • Accepted: 31 March 1989 |
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| Abstract |
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Methylprednisolone “pulse” therapy was performed on 22 patients of childhood nephropathies who
showed resistance to conventional therapy. The diseases included steroid-resistant or frequent relaps-
ing nephrotic syndrome including minimal change nephrotic syndrome, focal segmental glomer-
ulosclerosis, membranous nephropathy, mesangioproliferative glomerulonephritis, Henoch-Schonlein
purpura nephritis and SLE nephritis. Methylprednisolone 30 mg/kg/day was administered
intravenously over one hour, which was repeated 6 times on every other day.
Sixteen of 22 patients (73%) and 11 of 13 patients (85%) with minimal change nephrotic syndrome
responded to methylprednisolone pulse therapy. There were no serious side effects.
These findings suggest that methylprednisolone pulse therapy may benefit in childhood nephropath-
ies resistant to conventional therapy. |
| Key Words:
Methylprednisolone pulse therapy |
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