Journal of the Korean Pediatric Society 1989;32(9):1259-1264.
Published online September 30, 1989.
Methylprednisolone Pulse Therapy in Childhood Nephropathies.
Moon A Kim, Pyung Kil Kim
Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
소아 신질환 환아에서 Pulse Therapy의 치료 효과
김문아, 김병길
연세대학교 의과대학 소아과학교실
Received: 25 January 1989   • Accepted: 31 March 1989
Abstract
Methylprednisolone “pulse” therapy was performed on 22 patients of childhood nephropathies who showed resistance to conventional therapy. The diseases included steroid-resistant or frequent relaps- ing nephrotic syndrome including minimal change nephrotic syndrome, focal segmental glomer- ulosclerosis, membranous nephropathy, mesangioproliferative glomerulonephritis, Henoch-Schonlein purpura nephritis and SLE nephritis. Methylprednisolone 30 mg/kg/day was administered intravenously over one hour, which was repeated 6 times on every other day. Sixteen of 22 patients (73%) and 11 of 13 patients (85%) with minimal change nephrotic syndrome responded to methylprednisolone pulse therapy. There were no serious side effects. These findings suggest that methylprednisolone pulse therapy may benefit in childhood nephropath- ies resistant to conventional therapy.
Key Words: Methylprednisolone pulse therapy




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