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Specific Antibody Response in House Dust Mite Asthmatics on Immunotherapy.

Journal of the Korean Pediatric Society 1989;32(9):1282-1287.
Published online September 30, 1989.
Specific Antibody Response in House Dust Mite Asthmatics on Immunotherapy.
Won Sup Shin, Bub Sung Kim, Sang Il Lee
Department of Pediatrics, Paik Hospital, Inje University, Seoul, Korea
알레르기 면역치료시 혈청 면역글로불린의 동태에 관한 연구
신원섭, 김법성, 이상일
인제대학교 서울백병원 소아과학교실
Received: 17 August 1989   • Accepted: 17 August 1989
The immunotherapy has become a useful and effective method to treat allergic respiratory diseases. It is a logical assumption that immunotherapy produces symptom relief as a result of immunologically specific response. This study was performed to delineate the IgE, IgG and IgG4 responses to immunotherapy, and their relationships. We selected the six asthmatic children on immunotherapy with Dermatophagoides pteronyssinus (Dp). A set of samples from each patients were drawn, one before the treatment and another after a year treatment. The specific antibodies (IgE,IgG and IgG4) were measured by RAST (Pharmacia, Sweden), and we take the logarythmic values of each radioactivity (CPM; count per minute). These values were converted to arbitrary unit (AU), the scale was 0~10 AU. Specific IgE antibody response against Dp did not change with the treatment (p=0.83). Dp-specific IgG antibody response (p=0.012) were remarkable with immunotherapy in comparison to the IgG4 response (p=0.071). In conclusion, clinical effect of immunotherapy is due to the generation of IgG antibodies rather than the suppression of IgE response. Among the IgG responses, IgG-subclasses other than IgG4 might be the main responder to the immunotherapy.
Key Words: Immunotherapy, Specific Immunoglobulin, IgE, IgG, IgG4

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