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Four Cases of Childhood Systemic Lupus Erythematosus.

Journal of the Korean Pediatric Society 1990;33(2):264-273.
Published online February 28, 1990.
Four Cases of Childhood Systemic Lupus Erythematosus.
Jun Ah Jeong1, Young Mi Kim1, Eun Sook Suh1, Sung Ho Kim1, Chin Moo Kang1, Sang Sook Lee2, Chai Hong Chung2
1Department of Pediatrics, Keimyung University, School of Medicine, Taegu, Korea
2Department of Pathology, Keimyung University, School of Medicine, Taegu, Korea
전신성 홍반성 낭창 4례
정준아1, 김영미1, 서은숙1, 김성호1, 강진무1, 이상숙2, 정재홍2
1계명대학교 의과대학 소아과학교실
2계명대학교 의과대학 병리학교실
Received: 29 June 1989   • Accepted: 21 September 1989
Systemic Lupus Erythematosus (SLE) is a rare entity in pediatric age and prognosis is poor due to higher incidence of renal involvement in children. Authors experienced four cases of SLE, aged between 9-13 years. All cases were female. The diagnosis was based on “The 1982 revised criteria for SLE (by American Rheumatism Association). All cases had fever on admission and the butterfly facial rash was observed in 3 cases and joint involvement in 2 cases. All of them show characteristic immunofluorescent skin test and positive antinuclear antibody and three of them show decreased C3 and C4 level. Skin biopsy was done in all cases, showing chronic inflammatory changes. Renal involvement was observed in two among three cases in which renal biopsy was performed. Electron microscopic findings of the kidney showed electron dense deposits in basement membrane and mesangeal area in both cases. One case expried due to intracranial hemorrhage and two cases improoved with corticosteroid. One case who resisted to the corticosteroid therapy, showed improvement with chlorquine. Brief review of literature wase made.
Key Words: Systemic Lupus Erythematosus

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