Journal of the Korean Pediatric Society 1990;33(7):915-922.
Published online July 31, 1990.
The Effect of Low-Dosage Alpha-Interferon Therapy in Children with Chronic Active Hepatitis B.
Hee Kyung Kim, Sung Min Choi, Cheol Woo Ko, Kun Soo Lee, Ja Hoon Koo, Doo Hong Ahn
Department of Pediatrics, College of Medicine, Kyungpook National University, Taegu, Korea
소아의 B형 만성활동성간염에 대한 Low-Dosage Alpha Interferon의 치료 효과
김희경, 최성민, 고철우, 이건수, 구자훈, 안두홍
경북대학교 의과대학 소아과학교실
Received: 27 February 1990   • Accepted: 20 March 1990
Abstract
A clinical trial was conducted to determine the effect of low-dosage recombinant a-interferon therapy in children with HBs Ag and HBe Ag positive chronic active hepatitis. Studied patients consist of 7 biopsy-proven children (aged 6.5-11.5 yr). After 16 weeks of therapy, following results were obtained. Out of 7 HBe Ag positive cases, 5 cases (71.4%) were converted to HBe Ag negative state. One of two HBV-DNA positive cases was converted to HBV-DNA negative and the other one showed decreased in titer. None showed any change of HBs Antigenecity. Six patients who had high level of serum transaminase before therapy showed normal range levels after completion of therapy. Cellular immune indices (total T, T4, T8 cells and T4/T8 ratio) before therapy showed decreased total T, increased T4, decreased T8 cells and increased T4/T8 ratio. These changes of cellular immune indices were statistically significant compared to control. (p<0.05) In summary, it can be said that short-term effect of recombinant a-interferon therapy in children with chronic active hepatitis B was excellent. However, longterm effect of this therapy shoud be evaluated on more prolonged period of time.
Key Words: Chronic Active Hepatitis B, Alpha-Interferon




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