Journal of the Korean Pediatric Society 1990;33(9):1209-1215.
Published online September 30, 1990.
Vitamin K Dependent Hemorrhagic Disease of the Newborn and Infancy with Intracranial Hemorrhage.
Ji Eun Lee, Pal Dong Kim, Hong Dae Cha, Heung Sik Kim, Chin Moo Kang
Department of Pediatrics, School of Medicine, Keimyung University, Taegu, Korea
두개내출혈을 동반한 Vitamin K의존성 신생아 및 영아 출혈성 질환*
이지은, 김팔동, 차홍대, 김홍식, 강진무
계명대학교 의과대학 소아과학교실
Received: 25 May 1990   • Accepted: 31 July 1990
Eight cases of vitamin K dependent hemorrhagic disease of the newborn and infancy with intra- cranial hemorrhage were analysed clinically. Out of 8 cases, 3 cases developed the bleeding within 7 day of life and 5 cases after one month. Two cases had bleeding before initial feeding. Out of 6 cases who were fed before the onset of bleeding, 4 cases had breast feeding. Neurological abnormalities were seen in all cases and were associated with upper respiratory tract infection (2 cases), diarrhea (1 case) and bile duct obstruction (1 case). Subdural hemorrhage was most common, found in 5 cases followed by subarachnoid hemorrhage in 2 cases. Prolongtion of prothrombin time and anemia were noticed in all cases. One case had mild throm- bocytopenia. Prophylactic dose of vitamin Kx at birth was given in only one case. Therapeutic doses of vitamin Ki injection were given to all cases with improvement of gross bleeding and 2 cases showed neur- ological improvement. According to the result of this study, administration of the prophylactic dose of vitamin Kx at birth was necessary for the prevention of serious conditions associated with the vitamin K dependent hemorrhagic disease of the newborn and infancy, especially to the cases of breast feeding.
Key Words: Vitamin K, Hemorrhagic disease, Intracranial hemorrhage

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