A Clinical Study of Periventricular-Intraventricular Hemorrhage in Very Low Birth Weight Infants.

Chey, Myoung Jae; Chang, Young Pyo; Choi, Jung Hwan; Hwang, Yong Seung; Yun, Chong Ku; Kim, In One; Yeon, Kyung Mo

Original Article

Journal of the Korean Pediatric Society 1990;33(10):1341-1352.
Published online October 31, 1990.

A Clinical Study of Periventricular-Intraventricular Hemorrhage in Very Low Birth Weight Infants.

Myoung Jae Chey¹, Young Pyo Chang¹, Jung Hwan Choi¹, Yong Seung Hwang¹, Chong Ku Yun¹, In One Kim², Kyung Mo Yeon²

¹Department of Pediatrics, Seoul National University, College of Medicine Seoul, Korea
²Department of Radiology, Seoul National University, College of Medicine Seoul, Korea

1,500그람 미만의 저출생 체중아에서 뇌실 주위 및 뇌실내 출혈의 임상적 연구*

최명재^¹^, 장영표^¹^, 최중환^¹^, 황용승^¹^, 윤종구^¹^, 김인원^²^, 연경모^²

^¹서울대학교 의과대학 소아과학교실
^²서울대학교 의과대학 방사선과학교실

Received: 30 May 1990 • Accepted: 11 June 1990

Abstract

34 very low birth weight infants weighing 1,500 gms or less, who were admitted to the neonatal intensive care unit of Seoul National University Children’s Hospital, were routinely studied with serial real-time brain ultrasonography from August 1, 1986 to July 31, 1988. Their medical records and the results of brain ultrasonography were analyzed to evaluate propor- tion, severity, timing, clinical findings, outcome, associated periventricular echodensity and the various risk factors of perivetricular intraventricular hemorrhage (PV-IVH). The results were summarized as follows: 1) The proportion of PV-IVH in the study population was 50.0%. 2) The severity of PV-IVH was grade 1 in 7 cases (41.2%), grade II in 4 cases (23.6%), grade III in 3 cases (17.6%) and grade IV in 3 cases (17.6%). 3) In view of periventricular echodensity, periventricular hemorrhagic infarction was detected in 17.6% of PV-IVH and periventricular leukomalacia was detected in 35.3%. The latter was detected in 38.2% of the study population. 4) Poor motility and bradycardia were statistically significant clinical findings associated with PV-IVH (p<0.05). 5) The proportion of very low birth weight infants who died of PV-IVH was 23.5% and was 0% for grade 1, 25.0% for grade II, 33.3% for grade III and 66.7% for grade IV. 6) Multiple logistic regression analysis for the risk factors of PV-IVH showed that lesser ges- tational age and lower arterial Pa02 were the most significant contributing factors (p<0.05).

Key Words: Periventricular-intraventricular hemorrhage, Periventricular echodensity, Very low birth weight infant