Journal of the Korean Pediatric Society 1990;33(11):1510-1515.
Published online November 30, 1990.
Measles in Previously Vaccinated Children during Measles Epidemics.
Hwan Gyu Park1, Jeong Wan Yoo1, Soh Yeon Kim1, Young Mo Shon1, Sung Kyu Lee1, Kyung Soon Song2
1Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
2Department of Clinical Pathology, College of Medicine, Yonsei University, Seoul, Korea
홍역 유행시 홍역 예방 접종아의 홍역 이환에 관한 연구* - 혈청내 홍역 IgM 항체 유무에 따른 일차 백신 실패율에 대한 조사
박환규1, 유정완1, 김소연1, 손영모1, 이승규1, 송경순2
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 임상병리과학교실
Received: 16 June 1990   • Accepted: 30 August 1990
Abstract
A clinical study was made on 98 cases of measles patients admitted to YoungDong Severance Hospital during the period of 7 months from June to December 1989. The patients with measles were evaluated for presence of measles specific IgM antibody in serum, clinical symptom and vaccination history. We obtained the following results: 1) Out of 98 patients, 62 patients (63.3%) were vaccinated children and 36 patients (36.7%) were unvaccinated children. Among them, measles specific IgM antibody were positive in 39 vaccinated children (62.9%) and 32 unvaccinated children (88.9%). 2) Among the measles patients, 31 patients (31.6%) were in the unvaccinated group age, that is, less than 15 months old, and 35 patients (37.5%) were in the school age group, that is greater than 6 years. 3) Among the 71 patients diagnosed serologically, 21 patients (29.6%) were negative in the clinical diagnostic criteria. 4) Complications of measles were pneumonia, otitis media and sinusitis in order of frequency and they were present in 60.2% of the patients. The complication rate was slightly higher in the unvac- cinated group than in the vaccinated group. In conclusion, primary vaccine failure seems to be the cause of measles during epidemics in more than 62.9% of the children. Thirty percent of patients positive for measles specific IgM antibody did not show typical symptoms of measles. Thus for the accurate evaluation of diagnosis of measles and efficacy of measles vaccination, not only should clinical symptoms be relied on but serologic tests should also be done.
Key Words: Measles, Measle$ Specific IgM Antibody, Vaccine Failure




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