Journal of the Korean Pediatric Society 1991;34(1):66-73.
Published online January 31, 1991.
Therapeutic effects of plasmapheresis in Guillian-Barre syndrome.
Sung Jin Chang, Sun Hee Jung, Eun Sook Suh, Chin Moo Kang
Department of Pediatrics, Keimyung University, School of Medicine, Taegu, Korea
Guillain-Barré 증후군에 있어서 혈장교환술의 치료 효과*
장성진, 정선희, 서은숙, 강진무
계명대학교 의과대학 소아과학교실
Received: 17 August 1990   • Accepted: 29 October 1990
Abstract
Although the exact mechanism of the immunologic injury is unknown, the pathogenesis of the Guillain-Barr受 syndrome is explained as an autoimmune attack directed against to peripheral nervous myelin. So plasmapheresis is tried for treatment of Guillain-Barr즌 syndrome. Authors analysed 12 cases af Guillain-Barr受 syndrome who were treated with plasmapheresis and compared the results with that of the 13 cases, treated with conventional therapy. Duration between onset and begining of recovery is shortened in plasmapheresis group. The motor power score at discharge was 4.2±1.0 in pheresis group, 3.0±l.l in conventional therapy group. The recovery rate of the pheresis and conventional therapy group was 41.7% and 7.7% re- spectively. No cases were expired in pheresis group contrast to 23,1% mortality in conventional therapy group. Plasmapheresis is of significant beneits for the treatment of Guillain-Barr受 syndrome in time until onset of improvement, improvement motor power and the recovery rate. A brief review of the literature was made.
Key Words: Guillain-Barre syndrome, Plasmapheresis




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