| Altered secretion of arginine vasopressin in children with CNS diseases. |
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Kun Whe Kim1, Eun Sook Kim1, Cheol Woo Ko1, Ja Hoon Koo1, Doo Hong Ahn1, Won Jung Lee2 |
1Department of Pediatrics, School of Medicine Kyungpook National University, Taegu, Korea
2Department of Physiology, School of Medicine Kyungpook National University, Taegu, Korea |
| 소아의 중추신경계질환이 혈장 Arginine
Vasopressin에 미치는 영향 |
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김건회1, 김은숙1, 고철우1, 구자훈1, 안두홍1, 이원정2 |
1경북대학교 의과대학 소아과학교실
2경북대학교 의과대학 생리학교실 |
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Received: 23 January 1991 • Accepted: 20 February 1991 |
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| Abstract |
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A prospective study was conducted to see the pattern and mechanism of arginine vasopressin (AVP)
secretion in children with CNS diseases. Study population consisted of 21 cases with aseptic meningi-
tis (meningitis group) and another 21 cases with viral encephalitis or encephalopathy (encephalitis
group), who had been admitted to our Pediatric Department during 10 months’ period from April 1985
to January 1986. Seventeen healthy children were used as control.
The following results were obtained;
On the admission day, serum osmolality showed no difference between study groups and control
(meningitis group, 280.5±8.3 and encephalitis group, 281.4±18.4 versus control, 283.7±5.9mOm/
kg). Plasma aldosterone showed elevated level in encephalitis group (81.1 ±82.4) compared with
control (16.4±17.7 ng/dl). Plasma cortisol in menigitis group (19.0±10.5) and encephalitis group (33.
9±23.6) were both elevated compared with the control (10.3±3.6 ug/dl), and these values returned
to normal range during subsequeunt hospital days.
Plasma AVP, AVP/Na ratio and AVP/osmolarity ratio on the admission day also showed elevated
values in both meningitis (14.2±9.0 pg/ml, 101.5±63.7 and 48.6±29.0) and encephalitis group (20.
l±11.8pg/ml, 142.5±81.3 and 70.9±40.7) compared with control (9.1 ±3.2 pg/ml, 63.3±21.8 and
31.9±10.7). And the values returned to normal range during subsequent hospital days. Plasma AVP
values according to the concentration of serum sodium and osmolarity revealed that in about half of
the study population elevated level of plasma AVP was noted. Though in the majority of cases, during
the subsequent hospital days, these values returned to normal, elevated level persisted in some.
The relationship between plasma aldosterone, cortisol and AVP according to the presence of
dehydration on the admission day revealed that;
1) aldosterone was increased in encephalitis group with dehydration. However, plasma AVP was
increased also in both meiningitis and encephalitis group without dehydration.
2) Cortisol was increased in meningitis group without dehydration and encephalitis group with
dehydration. However, plasma AVP was also increased in encephalitis group without dehydration.
In summary, it can be concluded from the present stduy that during the early phase of CNS diseases,
the secretion of AVP is increased, and in some cases increased secretion persisits for 7 days or longer.
And the mechanism of altered secretion of AVP seems to come from the stimulus to the supraoptico-
hypophyseal system from the inflammatory process of the CNS disease. |
| Key Words:
arginine vasopressin, CNS diseases |
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