| Predictive factors and initial selection of antibiotics in neonatal sepsis. |
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Dong Chul Park, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han |
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Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea |
| 신생아 패혈증의 예측인자 및 초기 항생제 선택 |
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박동철, 이철, 박국인, 남궁란, 한동관 |
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연세대학교 의과대학 소아과학교실 |
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Received: 29 October 1990 • Accepted: 28 December 1990 |
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| Abstract |
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For simplifying and standardizing the interpretation of usual findings for neonatal sepsis, prenatal
and perinatal factors, clinical symptoms and signs, method of management and hematologic findings
were evaluated as a screening test.
From the data obtained, a scoring system was formulated that assigns a score of 3 for diarrhea, 1.
5 for tachypnea, 1.5 for cyanosis, 1 for umbilical vessel catheterization, 1 for intravenous fluid
therapy, 0.5 for abdominal distension, 0.5 for vomiting, 2 for immature/total neutrophil count ratio,
2 for C-reactive protein, 1.5 for leukocytosis, 0.5 for thrombocytopenia.
There were 129 evaluations for sepsis (60 infants were with sepsis and the others were non-infected).
In case of the score over 4, the sensitivity for neonatal sepsis was 48.3%, specificity was 89.9%,
positive predictive value was 80.6% and negative predictive value was 66.7%.
The antibiotic sensitivities of microorganisms causing neonatal sepsis were 82.5% of cephalothin,
81.0% of clindamycin and 94.1% of amikacin. |
| Key Words:
Neonatal Sepsis, Scoring System |
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