| Inhibitory effects of several drugs to intestinal secretory stimulation of heat-labile enterotoxin produced by enterotoxigenic E. coli. |
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Kyung Rae Moon1, Sang Kee Park1, Young Wook Chun1, Kap Seung Kim1, Young Bong Park1, Young Cheon Na2, Jeong Hyung Park2, Hyun Kook Lee2, Nam Ung Yang2 |
1Department of Pediatrics, Chosun University, College of Medicine, Kwangju, Korea
2Department of Microbiology, Chosun University, College of Medicine, Kwangju, Korea |
| 장독소원성 대장균생산 이열성장독소의 장액분비자극에
대한 각종 약제의 억제효과 |
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문경래1, 박상기1, 천영욱1, 김갑승1, 박영봉1, 나영천2, 박정형2, 이현국2, 양남웅2 |
1조선대학교 의과대학 소아과학교실
2조선대학교 의과대학 미생물학교실 |
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Received: 18 March 1991 • Accepted: 14 June 1991 |
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| Abstract |
For exploitation of new antidiarrheal agents to heat-labile enterotoxin (LT) produced by enterotox-
igenic E. coli, we have tested several drugs by rabbit ileal loop assay and obtained some significant
results
. L-glutathione (20 mg), P-chloromercuriphenyl sulfonic acid (20 mg) and water heating extract
of Prunus mume (20 mg) reduced LT-mediated intestinal fluid secretion in rabbit ileal loop assay by
92%, 87%, 92% respectively. Maleate, quinacrine HC1 and mixed antioxidant (150 mg) in usual dosage
unduced diarrhea by 32%, 37%, 52% respectively. Berberine sulfate and indomethacin did not showed
any drug effects.
We concluded that L-glutathione and water heating extract of Prunus mume would become
excellent antidiarrheal drug if these agents were enclosed with coating agent digested by intestinal
enzymes. |
| Key Words:
Enterotoxigenic E.coli, Heat-labile enterotoxin, L-gluthathione, Prunus mume |
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