Journal of the Korean Pediatric Society 1991;34(10):1365-1372.
Published online October 31, 1991.
Congenital cytomegalovirus infection: incidence and clinical outcome.
Young Mo Sohn1, Kook In Park1, Chul Lee1, Dong Kwan Han1, Won Young Lee2
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
2Department of Microbiology, Yonsei University College of Medicine, Seoul, Korea
선천성 거대세포 바이러스 감염 : 발생빈도와 임상경과에 관한 연구*
손영모1, 박국인1, 이철1, 한동관1, 이원영2
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 미생물학교실
Received: 16 May 1991   • Accepted: 23 July 1991
In order to assess the rate of congenital cytomegalovirus (CMV) infection in newborns, CMV IgG antibody was studies at about 37.5 weeks gestation in 309 mothers and a positive rate of 96.4% was obtained. Virus culture for CMV from urine of 514 neonates less than 1 week after birth resulted in CMV growth in 6 neonates showing a 1.2% congenital infection rate. In 220 cases where cord blood was obtainable, CMV IgM antibody was positive in 4 cases, but we couldn’t isolate CMV from urine of those 4 newborn infants until 6 weeks culture. As of present, there is no treatment for congenital CMV infection and therfore, prevention of neurologic sequelae is the most important factor. The rate of CMV infection during pregnancy and risk of primary infection in women should be assessed together with rate of congenital infections. The natural history, mode of transnission, epidemiology of congenital CMV infection in this country will help identifying the pathogenesis of the disease.
Key Words: Cyomegalovirus, Congenital Infection, Rapid diagnosis

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