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Clinical efficacy and safety of lamotrigine monotherapy in newly diagnosed pediatric patients with epilepsy

Korean Journal of Pediatrics 2010;53(4):565-570.
Published online April 15, 2010.
Clinical efficacy and safety of lamotrigine monotherapy in newly diagnosed pediatric patients with epilepsy
Ji Hye Han, Jung Eun Oh, Sun Jun Kim
Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea
간질 환아에서 Lamotrigine 초기 단독 요법의 효능 및 안정성에 대한 연구
한지혜, 오정은, 김선준
전북대학교 의학전문대학원 소아과학교실
Correspondence: 
Sun Jun Kim, Email: sunjun@chonbuk.ac.kr
Abstract
Purpose
: To verify the efficacy and safety of lamotrigine (LTG) monotherapy in newly diagnosed children with epilepsy.
Methods
: We prospectively enrolled 148 children who had undergone LTG monotherapy at our institution between September 2002 and June 2009. Twenty-nine patients were excluded: 19 due to incomplete data and 10 were lost to follow up. The data of the remaining 119 patients was analyzed.
Results
: We enrolled 119 pediatric epilepsy patients (aged 2.8-19.3 years; 66 males and 53 females) in this study. Out of 119 patients, 29 (25.2%) had generalized epilepsy and 90 (74.8%) had partial epilepsy. The responses of seizure reduction were as follows: Seizure freedom (no seizure attack for at least 6 months) in 87/111 (78.4%, n=111) patients; partial response (reduced seizure frequency compared to baseline) in 13 (11.7%) patients; and persistent seizure in 11 (9.9%) patients. The seizure freedom rate was in 81.6% in patients with partial seizure (75.9% for complex partial seizure and 90.9% for benign rolandic epilepsy) and 44.8% in patients with generalized epilepsy (30.0% for absence seizure, 35.7% for juvenile myoclonic epilepsy patients, and 100.0% for idiopathic generalized epilepsy patients). Adverse reactions were reported in 17 (14.3%) patients, and 8 patients (6.7%) discontinued LTG because of rash and tic. No patient experienced severe adverse reaction such as Stevens-Johnson syndrome.
Conclusion
: LTG showed excellent therapeutic response and had few significant adverse effects. Our findings report may contribute in promoting the use of LTG monotherapy in epileptic children.
Key Words: Lamotrigine, Efficacy, Safety, Epilepsy, Child


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