| Effects of inhaled corticosteroids on bone mineral density and bone metabolism in children with asthma |
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Ic Sun Choi1, Jung Hye Byeon1, Seung Min Lee2, Kyong Suk La1, Yeon Joung Oh3, Young Yoo1, Kee Hyoung Lee3, Ji Tae Choung1 |
1Department of Pediatrics, Environmental Research Center, Korea University Anam Hospital, Seoul, Korea
2Environmental Research Center, Korea University Anam Hospital, Seoul, Korea
3Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea |
| 천식 환아에서 흡입용 스테로이드의 사용이 골밀도와 골대사에 미치는 영향 |
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최익선1, 변정혜1, 이승민2, 라경숙1, 오연정3, 유영1, 이기형3, 정지태1 |
1고려대학교 의과대학 소아과학교실, 고려대학교 안암병원 환경보건센터
2고려대학교 안암병원 환경보건센터
3고려대학교 의과대학 소아과학교실 |
Correspondence:
Young Yoo, Email: yoolina@korea.ac.kr
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| Abstract |
Purpose
: Inhaled corticosteroids (ICS) are used as first-line agents for the treatment of persistent asthma; however, their use is accompanied by apprehension of potential systemic adverse effects. This study aimed to assess the effects of ICS on bone mineral density (BMD) and bone metabolism in children with asthma.
Methods
: From February 2008 to September 2008, 26 asthmatic children treated with ICS (ICS group), 15 asthmatic children treated with leukotriene receptor antagonist (LTRA) (LTRA group), and 30 healthy children (Control group) were selected from the Korea University Anam Hospital. BMD and serum bone-specific alkaline phosphatase (BALP) levels were measured. The asthmatic children underwent spirometry and methacholine bronchial challenge test.
Results
: There were no significant differences in BMD in the lumbar spine (P=0.254) and proximal femur (P=0.297) among the 3 groups. The serum BALP levels were significantly higher in both the ICS (P=0.017) and LTRA (P=0.025) groups than in the Control group. None of the parameters pertaining to ICS use, such as the mean daily dose during the last 6 months, the total cumulative dose, duration of use, and age of commencement of use, showed significant correlations with BMD (P>0.05 for all parameters).
Conclusions
: We demonstrated that a low dose of ICS does not exert any significant adverse effect on bone metabolism in asthmatic children. These findings support the current recommendations with regard to the use of ICS for asthmatic children. |
| Key Words:
Inhaled Corticosteroids, Bone Mineral Density, Bone Metabolism, Asthma, Children |
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