| Epidemiologic and clinical features in children with acute lower respiratory
tract infection caused by human metapneumovirus in 2006-2007 |
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Gwi Ok Park1, Ji Hyun Kim1, Jae Hee Lee1, Jung Ju Lee1, Sin Weon Yun1, In Seok Lim1, Dong Keun Lee1, Eung Sang Choi1, Byoung Hoon Yoo,1, Mi Kyung Lee2, Soo Ahn Chae1 |
1Departments of Pediatrics, College of Medicine, Chung Ang University, Seoul, Korea
2Departments of Laboratory Medicine, College of Medicine, Chung Ang University, Seoul, Korea |
| 2006-2007년 소아 급성 하기도 감염증에서 유행한 메타뉴모바이러스의 유행 및 임상 양상 |
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박귀옥1, 김지현1, 이재희1, 이정주1, 윤신원1, 임인석1, 이동근1, 최응상1, 유병훈1, 이미경2, 채수안1 |
1중앙대학교 의과대학 소아과학교실
2중앙대학교 의과대학 진단검사의학과교실 |
Correspondence:
Soo Ahn Chae, Email: kidbrain@korea.com
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| Abstract |
Purpose
: The causes of acute lower respiratory tract infection (ALRTI) are mostly attributable to viral infection, including respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A/B (IFV A/B), or adenovirus (ADV). Several Korean studies reported human metapneumovirus (hMPV) as a common pathogen of ALRTI. However, studies on seasonal distribution and clinical differences relative to other viruses are insufficient, prompting us to perform this study.
Methods
: From November 2006 to October 2007, we tested nasopharyngeal aspiration specimens in children hospitalized with ALRTI with the multiplex reverse transcriptase-polymerase chain reaction to identify 6 kinds of common pathogen (hMPV, RSV, PIV, IFV A/B, and ADV). We analyzed positive rates and clinical features by respiratory chart review.
Results
: We detected 38 (8.4%) hMPV-positive cases out of 193 (41.8%) virus-positive specimens among 462 patients. HMPV infection prevailed from March to June with incidence peaking in April. HMPV-positive patients were aged 15 years (76.3%), and the ratio of boys to girls was 1.2:1. The median age was 27 months. HMPV primarily caused pneumonia (76.3 %) (P=0.018). Average hospitalization of HMPV-associated ALRTI patients was 5.8 days. In addition, they showed parahilar peribronchial infiltration (100%) on chest X-ray, normal white blood cell count (73.7%), and negative C-reactive protein (86.8 %) (P>0.05). All hMPV-positive patients recovered without complication.
Conclusion
: HMPV is a common pathogen of ALRTI in Korean children, especially in 1-5 year olds, from March to May. Immunocompetent children diagnosed with hMPV-associated ALRTI may have a good prognosis. |
| Key Words:
Human metapneumovirus, Respiratory infections, Children |
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