| Rotavirus-associated neonatal necrotizing enterocolitis |
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Hyun Joo Seo, Yu Jin Jung, Soo Kyung Park, Seo Hui Choi, Ji Hyuk Lee, Myo Jing Kim, Yun Sil Chang, Won Soon Park |
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Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
| 로타바이러스 감염이 관련된 신생아 괴사성 장염 |
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서현주, 정유진, 박수경, 최서희, 이지혁, 김묘징, 장윤실, 박원순 |
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성균관대학교 의과대학 삼성서울병원 소아청소년과 |
Correspondence:
Won Soon Park, Email: wonspark@skku.edu
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| Abstract |
Purpose
: This study aimed to test whether rotavirus-associated necrotizing enterocolitis (RV+NEC) produced different clinical findings or outcomes from those of non-rotavirus necrotizing enterocolitis (RV-NEC).
Methods
: Eight patients from the RV+NEC group and 22 patients from the RV-NEC group diagnosed with modified Bell stage II or higher NEC were selected for this study. Fecal specimens from all infants were tested for rotavirus infection using a monoclonal antibody-based enzyme immunoassay (EIA). Clinical, radiographic, and clinical outcome data were analyzed retrospectively.
Results
: RV+NEC infants had a significantly higher birth weight and were born at a significantly higher gestational age (33.5¡¾3.3 weeks vs. 29.3¡¾4.4 weeks; P=0.01). There were no differences in the occurrence of thrombocytopenia, mural gas, and pneumoperitoneum between the 2 groups. However, portal vein gas was more common in the RV+NEC group (88% vs. 9%; P<0.01). Neither the incidence of Bell stage III (or higher) NEC nor surgical intervention differed between the two groups. The number of complications and mortality rates were also similar.
Conclusion
: Rotavirus-associated NEC occurs in infants with a higher birth weight and those born at a greater gestational age. However, the severity of the condition and the resulting outcomes did not differ from those for infants affected by non-rotavirus NEC. |
| Key Words:
Rotavirus infections, Enterocolitis, Necrotizing, Newborn |
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