Korean Journal of Pediatrics 2008;51(11):1185-1190.
Published online November 15, 2008.
The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old
Soo Young Lee1, Ga Young Kwak1, Hye Rin Mok1, Jong Hyun Kim1, Jae Kyun Hur1, Kyung Il Lee1, Park Joon Su2, Sang Hyuk Ma3, Hwang Min Kim4, Jin Han Kang1
1Department of Pediatrics, The Catholic University of Korea
2Department of Pediatrics, Soon Cheon Hyang University
3Department of Pediatrics, Changwon Fatima Hospital
4Department of Pediatrics, WonJu Yonsei University
국내 11-12세 소아에서 Td 백신 추가접종의 면역원성과 안전성 평가
이수영1, 곽가영1, 목혜린1, 김종현1, 허재균1, 이경일1, 박준수2, 마상혁3, 김황민4, 강진한1
1가톨릭대학교 의과대학 소아과학교실
2순천향대학교 의과대학 소아과학교실
3창원파티마병원 소아청소년과
4연세대학교 원주의과대학 소아과학교실
Correspondence: 
Jin Han Kang, Email: kjhan@catholic.ac.kr
Abstract
Purpose
: This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea.
Methods
: Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2006 to April 2007. Diphtheria and tetanus anti-toxoid antibodies in sera were measured by ELISA just before vaccination and 4 weeks after vaccination to evaluate immunogenicity. Local and systemic adverse reactions observed for 4 weeks after vaccination to access reactogenicity.
Results
: 183 preadolescents were enrolled and mean age was 11.40±0.51 years old. All subjects achieved seroprotective diphtheria and tetanus anti-toxoid antibodies (titers ≥0.1 IU/mL) after Td booster vaccination. Among 183 vaccinees, 73.8% showed local adverse reactions and 37.2% systemic adverse reactions. Pain at injection site (66.1%) was the most common local reaction, and the most commonly shown systemic reaction was myalgia (17.5%). The adverse reactions were spontaneously relieved within three days after vaccination.
Conclusion
: Td vaccine in this study was high immunogenic and showed an acceptable tolerance in Korean preadolescents. Td booster vaccination at 11-12 years old is the most effective method to increase compliance of the vaccination and to decrease the incidence of diphtheria and tetanus.
Key Words: Diphtheria-Tetanus vaccine, Immunization, Efficiency, Safety


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