The immunogenicity and reactogenicity of Td booster vaccination
in Korean preadolescents, aged with 11-12 years old

Lee, Soo Young; Kwak, Ga Young; Mok, Hye Rin; Kim, Jong Hyun; Hur, Jae Kyun; Lee, Kyung Il; Su, Park Joon; Ma, Sang Hyuk; Kim, Hwang Min; Kang, Jin Han

Original Article

Korean Journal of Pediatrics 2008;51(11):1185-1190.
Published online November 15, 2008.

The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old

Soo Young Lee¹, Ga Young Kwak¹, Hye Rin Mok¹, Jong Hyun Kim¹, Jae Kyun Hur¹, Kyung Il Lee¹, Park Joon Su², Sang Hyuk Ma³, Hwang Min Kim⁴, Jin Han Kang¹

¹Department of Pediatrics, The Catholic University of Korea
²Department of Pediatrics, Soon Cheon Hyang University
³Department of Pediatrics, Changwon Fatima Hospital
⁴Department of Pediatrics, WonJu Yonsei University

국내 11-12세 소아에서 Td 백신 추가접종의 면역원성과 안전성 평가

이수영^¹^, 곽가영^¹^, 목혜린^¹^, 김종현^¹^, 허재균^¹^, 이경일^¹^, 박준수^²^, 마상혁^³^, 김황민^⁴^, 강진한^¹

^¹가톨릭대학교 의과대학 소아과학교실
^²순천향대학교 의과대학 소아과학교실
^³창원파티마병원 소아청소년과
^⁴연세대학교 원주의과대학 소아과학교실

Correspondence:
Jin Han Kang, Email: kjhan@catholic.ac.kr

Abstract

Purpose
: This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea.
Methods
: Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2006 to April 2007. Diphtheria and tetanus anti-toxoid antibodies in sera were measured by ELISA just before vaccination and 4 weeks after vaccination to evaluate immunogenicity. Local and systemic adverse reactions observed for 4 weeks after vaccination to access reactogenicity.
Results
: 183 preadolescents were enrolled and mean age was 11.40±0.51 years old. All subjects achieved seroprotective diphtheria and tetanus anti-toxoid antibodies (titers ≥0.1 IU/mL) after Td booster vaccination. Among 183 vaccinees, 73.8% showed local adverse reactions and 37.2% systemic adverse reactions. Pain at injection site (66.1%) was the most common local reaction, and the most commonly shown systemic reaction was myalgia (17.5%). The adverse reactions were spontaneously relieved within three days after vaccination.
Conclusion
: Td vaccine in this study was high immunogenic and showed an acceptable tolerance in Korean preadolescents. Td booster vaccination at 11-12 years old is the most effective method to increase compliance of the vaccination and to decrease the incidence of diphtheria and tetanus.

Key Words: Diphtheria-Tetanus vaccine, Immunization, Efficiency, Safety