Korean Journal of Pediatrics 2008;51(3):286-292.
Published online March 15, 2008.
Analysis on the association between EEG and 2-deoxy-2-[18F]-D-glucose (FDG)-PET findings in children with epilepsy
Yun Jung Hur1, Joon Soo Lee1, Jong Doo Lee2, Heung Dong Kim1
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
2Department of Radiology, Yonsei University College of Medicine, Seoul, Korea
소아 간질 환아에서 뇌파와 PET과의 연관성에 대한 분석
허윤정1, 이준수1, 이종두2, 김흥동1
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 영상의학과학교실
Heung Dong Kim, Email: hdkimmd@yumc.yonsei.ac.kr
: We performed EEG and PET on children with epilepsy concomitantly in order to evaluate the effects of epileptiform and non-epileptiform discharge of EEG on glucose metabolism.
: Seventy three children with epilepsy who had PET and EEG simultaneously were included in our study. The subjects were classified in two ways: (1) based on the frequency of epileptiform discharge and (2) the severity of non- epileptiform discharge. We evaluated the clinical aspects of their seizures, the severity of focal slow waves during the interictal period with the frequency of spikes or sharp waves in order to compare with the PET results.
: The subjects were divided by the frequency of epileptiform discharge, with 13 in the no/rare group, 7 in the occasional group, and 53 children in the frequent group. The concordant rates with PET in each group were 0%, 42.9%, and 67.9%, respectively, showing high correlations with the frequency of epileptiform discharge (P<0.05, r=0.491). The subjects as divided by the severity of non-epileptiform discharge were 15 in the no group, 25 in the infrequent group, 17 in the intermediate group, and 16 in the continuous group. The concurrence rates with PET for each group were 13.3%, 52.0%, 64.7%, and 68.8%, respectively, also showing a high correlation with the severity of non-epileptiform discharge (P<0.05, r= 0.365).
: Epileptiform discharge and non-epileptiform discharge in EEG showed a certain association with hypometabolism in PET. We recommend EEG to reduce false lateralization and to localize lesions in cases of high frequency and severity.
Key Words: Fluorodeoxyglucose F18, Positron-Emission Tomography, Electroencephalography

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