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Palliative effect of 131I-MIBG in relapsed neuroblastoma after autologous peripheral blood stem cell transplantation

Korean Journal of Pediatrics 2008;51(2):214-218.
Published online February 15, 2008.
Palliative effect of 131I-MIBG in relapsed neuroblastoma after autologous peripheral blood stem cell transplantation
Yong Jik Lee, Jeong Ok Hah
Department of Hematology/Oncology, Yeungnam University College of Medicine
자가 말초혈조혈모세포이식 후 재발된 신경모세포종 3예에서 131I-MIBG의 고식적 치료 효과
이용직, 하정옥
영남대학교 의과대학 소아과학교실
Correspondence: 
Jeong Ok Hah, Email: johah@med.yu.ac.kr
Abstract
Neuroblastoma is one of the most common extracranial solid tumor of childhood, and treatment of refractory neuroblastoma remains a significant clinical problem. Iodine-131-metaiodobenzylguanidine (131I-MIBG) therapy is an alternative approach to treat stage Ⅳ neuroblastoma. We report the palliative effect of 131I-MIBG in three cases of relapsed neuroblastoma after autologous peripheral blood stem cell transplantation. 131I-MIBG is an effective and relatively nontoxic palliative therapy resulting in reduction of pain and prolongation of survival.
Key Words: Relapsed neuroblastoma, 131I-MIBG, Palliative therapy


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