Korean Journal of Pediatrics 2007;50(11):1091-1096.
Published online November 15, 2007.
Carotid artery intima media thickness in obese children : relation with cardiovascular risk factors
Jin Lee1, Hyo Jin Kwon1, Moon Ho Park2, Ki Young Jang1, Kee-Hyoung Lee1, Kwang Chul Lee1, Chang Sung Son1, Joo Won Lee1
1Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
2Department of Neurology, College of Medicine, Korea University, Seoul, Korea
비만 소아에서 경동맥 내중막 두께와 심혈관질환 위험인자와의 상관관계
이진1, 권효진1, 박문호2, 장기영1, 이기형1, 이광철1, 손창성1, 이주원1
1고려대학교 의과대학 소아과학교실
2고려대학교 의과대학 신경과학교실
Correspondence: 
Kee-Hyoung Lee, Email: khlee218@kumc.or.kr
Abstract
Purpose
: The of common carotid artery intima media thickness (IMT) is an acknowledged noninvasive marker for early atherosclerotic changes. We investigate whether common carotid IMT is different between obese and normal-weight children and also evaluate the relationships IMT with cardiovascular risk factors.
Methods
: We collected the clinical data (age, sex, pubertal stage, body mass index) and measured blood pressure, glucose, insulin, lipid profiles and adiponectin in 49 obese children (mean age, 12 years) and 24 nonobese children as controls. The control group was composed of 24 nonobese children of the same age, sex and pubertal stage. We measured the carotid IMT of all subjects by B-mode ultrasound with a 7.5-MHz linear transducer and analyzed.
Results
: Obese children demonstrated a significantly thicker intima media (mean, 0.34 mm, peak, 0.42 mm) compared to the control group (mean, 0.31 mm, peak, 0.38 mm, P<0.01). IMT was significantly correlated to the BMI (r=0.431, P<0.01), age (r=0.317, P<0.01), total cholesterol (r=0.377, P< 0.01), triglyceride (r=0.253, P<0.05) and low-density lipoprotein cholesterol (r=0.289, P<0.05). Serum adiponectin was significantly lower in obese children than in controls (11.2 ng/mL vs. 14.7 ng/mL, P<0.05) and negatively related with IMT (r=-0.267, P<0.05).
Conclusion
: Obesity is associated with increased carotid artery IMT in children. Our results suggest vascular changes in obesity seem to occur already in childhood and vascular ultrasonography may helpful for screening cardiovascular complications in obese children.
Key Words: Aterial intima, Obesity, Child, Adiponectin


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