Korean Journal of Pediatrics 2006;49(12):1287-1295.
Published online December 15, 2006.
Clinical characteristics and risk factors for staphylococcal infections in neonatal intensive care unit
Min Kook Chung1, Jeong Ho Choi1, Jin Keun Chang1, Sung Hoon Chung2, Chong Woo Bae2, Sung Ho Cha2
1Department of Pediatrics, Hanil General Hospital
2Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea
신생아 중환자실에서 포도알균 감염에 대한 임상적 고찰과 위험 요인 조사
정민국1, 최정호1, 장진근1, 정성훈2, 배종우2, 차성호2
1한일병원 소아과
2경희대학교 의과대학 소아과학교실
Jin Keun Chang, Email: atomjin@empal.com
: The importance of staphylococcal infections in NICU has been emphasized in terms of increased resistant strains and increased incidence of morbidity and mortality. In this study, we inrestignted the clinical characteristics and risk factors for staphylococcal infections, and looked into sensitivity trends of antibiotics in the era of a high rate of methicillin-resistant staphylococcus aureus (MRSA) in our society.
: This study included 240 neonates with positive blood, urine and other sites cultures for staphylococci who were admitted to NICU of Hanil General Hospital and Kyunghee University Hospital from January 2000 to December 2004. The analyses included clinical characteristics of staphylococcal infections and the relationship of incidence rate among various factors, including invasive procedures.
: For 5 years, 3,593 patients were hospitalized in the NICU and 7,481 specimens were cultured from blood, urine, and other sites. During the study period, staphylococci were isolated from 240 patients, of whom 88 patients had MRSA, 41 patients methcillin sensitive staphylococcus aureus (MSSA), 63 patients S. epidermidis, 48 patients coagulase-negative staphylococcus (CNS) except S. epidermidis infections. The risk factors associated with staphylococcal infections were less than 37 weeks of gestational age, less than 7 on a 5 minutes Apgar score, receiving TPN, applied mechanical ventilation, use of central venous catheters and other tubes. The sensitivity to vancomycin was 100 percent. A relatively high sensitivity against teicoplanin, trimethoprim-sulfamethoxazole, chloramphenicol, clindamycin and low sensitivity against gentamicin and erythromycin were shown.
: To reduce staphylococcal infections in NICU, we need to monitor and manage premature neonates from the beginning of the birth process and to avoid as many invasive procedures as possible in NICU. Considering MRSA, control of preceding factors and early use of appropriate antibiotics is expected to reduce the morbidity and mortality caused by MRSA infections.
Key Words: Staphylococcus, Neonates, Clinical characteristics, Risk factor

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