Korean Journal of Pediatrics 2006;49(7):718-725.
Published online July 15, 2006.
Update in the etiology and treatment of sexual precocity
Mi Jung Park
Department of Pediatrics, College of Medicine, Inje University, Seoul, Korea
사춘기 조숙증의 원인 및 치료의 최신지견
인제대학교 의과대학 소아과학교실
Mi Jung Park, Email: pmj@sanggyepaik.ac.kr
The pubertal activation of gonadotrophin releasing hormone(GnRH) requires coordinated changes in excitatory or inhibitory amino acids, growth factors, and a group of transcriptional regulators. The age of onset of puberty is progressing to younger age. Factors affecting early puberty include genetic traits, nutrition(body fat) and exposure to endocrine disrupting chemicals. In rapidly progressing central precocious puberty, gonadotrophin releasing hormone(GnRH) agonists(GnRHa) appear to increase final height if treated early stage. Further large scaled long-term follow-up study of the effects of GnRHa on final height is needed.

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