Korean Journal of Pediatrics 2006;49(3):273-277.
Published online March 15, 2006.
Reye syndrome after acute enteritis during the neonatal period
Jun Suck Bang1, Sang Jung Nam1, Kyung Hwa Lee1, Eun Joo Bae1, Won Il Park1, Hyun Sook Lee2, Bae Young Son3, Hwan Suck Choi4, Hong Jin Lee1
1Department of Pediatrics, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University
2Department of Pediatrics, Sanggye Paik Hospital, College of Medicine, Inje University
3Department of Pediatrics, Seoul Samsung Medical Center, College of Medicine, Sungkyunkwan University
4Department of Pediatrics, Wonju Christian Hospital, College of Medicine, Yonsei University, Wonju, K
신생아기 장염에 의하여 발병된 Reye 증후군
방준석1, 남상정1, 이경화1, 배은주1, 박원일1, 이현숙2, 손배영3, 최환석4, 이홍진1
1한림대학교 의과대학 춘천성심병원 소아과
2인제대학교 의과대학 상계백병원 소아과
3성균관대학교 의과대학 삼성서울병원 소아과
4연세대학교 의과대학 원주기독병원 소아과
Hong Jin Lee, Email: hongjlee@hallym.ac.kr
: The reinfection rate of H. pylori reported before 13C-urea breath test(13C-UBT) era was higher than that of the post 13C-UBT era. Children are usually reluctant to receive invasive endoscopic evaluation for the reinfection of H. pylori, particularly when they are asymptomatic. The aim of the study is to discover the reinfection rate by different diagnostic tests, and to find out what causes the difference.
: Children confirmed to be eradicated from H. pylori were included in the study. Reinfection was evaluated by endoscopic biopsy based tests(n=34, mean age 11.5¡¾3.7 years) and/or a 13C- UBT(n=38, mean age 10.0¡¾3.6 years) at the time of 18 months after eradication. At first visit, H. pylori infection had been diagnosed by positive results from a rapid urease test, Giemsa stain and Warthin-Starry stain and/or a positive culture. Eradication was defined as negative results from all above tests 1-3 months after eradication therapy.
: Reinfection rate by endoscopic biopsy based tests was 35.3 percent(12/34). All patients had abdominal symptoms(P=0.000). Reinfection rate was 13.2 percent(5/38) by a 13C-UBT. Reinfection rate was higher in children with abdominal symptoms(P=0.008). There was no evidence that reinfection rate depended on the sex(P=0.694), age(P=0.827), diseases(peptic ulcers vs gastritis, P=0.730) and eradication regimen(P=0.087).
: Helocibacter pylori reinfection rate in Korean children was 13.2 percent per 18 months by a non-invasive test or 13C-UBT. Accurate determinations of the reinfection rate in children is affected by the compliance of the diagnostic tests. Non-invasive tests should be considered to investigate the reinfection rate in children.
Key Words: Organic acids , Serum ammonia , Aspirin

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