| Correlations of cord blood Ghrelin and leptin concentrations with anthropometry of appropriate for gestational age newborns |
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Jin Lee1, Se Na Moon2, So Hyun Park2, Min-Ho Jung2, Byung Kyu Suh2, Byung Churl Lee2 |
1Department of Pediatrics, Hanil General Hospital
2Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| 적정체중아 제대혈의 ghrelin 및 leptin 농도와 신체계측치의 관계 |
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이진1, 문세나2, 박소현2, 정민호2, 서병규2, 이병철2 |
1한일병원 소아과
2가톨릭대학교 의과대학 소아과학교실 |
Correspondence:
Byung Kyu Suh, Email: suhbk@catholic.ac.kr
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| Abstract |
Purpose
: Ghrelin stimulates the secretion of growth hormone and other pituitary hormones, and has orexigenic effects. It may have a physiologic role in fetal and neonatal growth. Leptin secreted by the adipocytes reflects fat mass in infants as well as adults. The aim of this study was to evaluate the relation of cord blood ghrelin and leptin levels to body weight(BW), body mass index(BMI), insulin-like growth factor-I(IGF-I) and insulin-like growth factor binding protein-3(IGFBP-3) levels in appropriate for gestational age(AGA) newborns.
Methods
: Sixty healthy AGA newborns(31 males and 29 females, gestational age[GA] 34-42 weeks) were included in this study, whose BW and BMI were measured at delivery. Umbilical cord venous blood samples were withdrawn, and ghrelin and leptin were measured by radioimmunoassay. Cord blood IGF-I and IGFBP-3 were determined by immunoradiometric assay.
Results
: The mean levels of ghrelin were inversely correlated with BW(r=-0.29, P<0.05) and GA (r=-0.28, P<0.05), but were not affected by gender. The mean levels of leptin levels showed positive correlation with BW(r=0.44, P<0.01), GA(r=0.36, P<0.01), and BMI(r=0.28, P<0.05). The leptin levels of females were higher than those of males. There was no gender difference in leptin levels in neonates under GA 37 weeks. However, the leptin levels of females were higher than those of males (P<0.01) in newborns with GA 37 weeks or over. There was no correlation between ghrelin and leptin levels. Ghrelin and leptin levels showed no relations to cord blood IGF-I and IGFBP-3 levels.
Conclusion
: These data suggest that cord blood ghrelin may have an inverse correlation with BW in AGA newborns, and leptin levels are positively correlated with BW and fat mass. Further study of ghrelin concentrations in cord blood is necessary to elucidate the physiological and pathological roles of ghrelin during the fetal and neonatal periods. |
| Key Words:
Ghrelin , Leptin , Newborn |
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