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Relationship between △FVC(% fall in FVC at the PC20 Dose of Methacholine) and Serum Eosinophil Cationic Protein(ECP) in 6-8 Year Old Children with Asthma

Korean Journal of Pediatrics 2005;48(10):1126-1131.
Published online October 15, 2005.
Relationship between △FVC(% fall in FVC at the PC20 Dose of Methacholine) and Serum Eosinophil Cationic Protein(ECP) in 6-8 Year Old Children with Asthma
Dong In Suh1, Jinho Yu2, Young Yoo3, Do Kyun Kim1, Hee Kang3, Young Yull Koh1
1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
2Department of Pediatrics, College of Medicine, Dongguk University, Gyeongju, Korea
3Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
6-8세 천식 환아에서 △FVC(메타콜린 PC20에서의 강제폐활량의 감소율)와 혈청 호산구 양이온 단백의 관계
서동인1, 유진호2, 유영3, 김도균1, 강희3, 고영률1
1서울대학교 의과대학 소아과학교실
2동국대학교 의과대학 소아과학교실
3고려대학교 의과대학 소아과학교실
Correspondence: 
Young Yull Koh, Email: kohyy@plaza.snu.ac.kr
Abstract
Purpose
: Bronchial hyperresponsiveness(BHR) is considered a hallmark of asthma. Increased levels of eosinophil cationic protein(ECP) have been identified in serum of asthma patients. Several studies have examined the relationship between serum ECP and bronchial responsiveness, expressed as methacholine PC20 in asthmatic patients, with conflicting results. The aims of this study were to examine the relationship between serum ECP and △FVC, another index of bronchial responsiveness, which reflects increased maximal airway response.
Methods
: Six to 8-year-old children with asthma(n=109) underwent methacholine bronchoprovocation testing. The PC20 dose of methacholine and △FVC were calculated for each individual from the methacholine dose response curves. Serum ECP levels and blood total eosinophil counts were also measured.
Results
: Serum ECP correlated with △FVC(r=0.217, P=0.023), as well as PC20(r=-0.208, P=0.030). However, blood eosinophil counts failed to show any correlations with △FVC(r=0.085, P=0.378) or PC20(r=-0.148, P=0.125). △FVC did not correlate with PC20(r=-0.079, P=0.417).
Conclusion
: Blood eosinophil activation is associated with both components of BHR including increased sensitivity and increased maximal response in 6-8 year old children with asthma.
Key Words: Bronchial hyperresponsiveness , △FVC , PC20 , Serum ECP , Asthma , Children


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