| Human Leukocyte Antigen(HLA) Genotypes and Thyroid Autoimmunity in Korean Patients with Type 1 Diabetes |
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So Young Kang1, Chung Ho Shin2, Sei Won Yang2, Myoung Hee Park3, Jeesuk Yu1 |
1Department of Pediatrics, Dankook University College of Medicine, Cheonan, Korea
2Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
3Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea |
| 한국인 제 1형 당뇨병 환자들의 HLA 유전자형 및 자가면역성 갑상선 질환의 병발 양상 |
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강소영1, 신충호2, 양세원2, 박명희3, 유지숙1 |
1단국대학교 의과대학 소아과학교실
2서울대학교 의과대학 소아과학교실
3서울대학교 의과대학 검사의학교실 |
Correspondence:
Jeesuk Yu, Email: dryujs@dankook.ac.kr
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| Abstract |
Purpose
: This study analyzed the expression of HLA-DR and DQ genotypes and anti-thyroid autoantibodies[anti-thyroid peroxidase(TPO) and anti-thyroglobulin(TG) antibodies] in Korean patients with type 1 diabetes(T1DM) to investigate the susceptible HLA alleles to T1DM in Korea and the prevalence of thyroid autoantibodies and their significance for the development of thyroid disorders.
Methods
: A total of 59 Korean patients with type 1 diabetes[26 males, median age 13.7 years(range 5.7-29.9 years), diabetes duration 7.6 years(-1.7-22.5 years)] were enrolled in this study, and 200 healthy Koreans without a family history of diabetes were selected as a normal control for the comparison of HLA genotypes. Seventeen patients with anti-TPO or anti-TG were followed [median duration 3.96 years(1 day-10.7 years)] with measurement of anti-TPO, anti-TG, T3, T4 or free T4, TSH levels and physical examinations. HLA-DR and DQ genotyping were done by PCR-SSO, PCR- SSCP, PCR-RFLP and PCR-SSP methods.
Results
: HLA analysis showed higher frequencies of HLA-DRB1*0301, *090102 and DQB1*0201, *030302 alleles, DRB1*0301/*090102, *090102/*090102 and DQB1 *0201/*030302, *030302/*030302, *0201/ *0302 genotypes in T1DM patients compared to controls(Pc<0.05). Fifteen(25.4 percent) had anti- TPO antibody, 12(20.3 percent) had anti-TG, 17(28.8 percent) had either autoantibody and 10(16.9 percent) had both autoantibodies. No clinical or subclinical hypothyroidism developed during follow- up after the first detection of anti-thyroid autoantibody. There was no significant correlation between thyroid autoimmunity and gender, onset age of T1DM, and diabetes duration, respectively(P>0.05).
Conclusion
: We thought this unique HLA-DR, DQ allele distribution might be an important factor for the low incidence of T1DM in Korea. And a high prevalence of thyroid autoantibodies in these populations suggests examinations of thyroid antibodies should be performed regularly. Optimal age for the initial screening and the frequency of re-screening for associated thyroid autoimmune diseases in T1DM remains to be determined through prospective follow-up. |
| Key Words:
Type 1 diabetes mellitus(T1DM) , HLA , Thyroid autoimmunity |
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