| Helper T Cell Polarizing Through Dendritic Cells |
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Manyong Han |
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Department of Pediatrics, College of Medicine, Pochon CHA University, Sungnam, Korea |
| 수지상세포를 통한 조력 T세포의 분화 - 알레르기 질환을 중심으로 - |
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한만용 |
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포천중문의과대학 분당차병원 소아과 |
Correspondence:
Manyong Han, Email: drmesh@cha.ac.kr
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| Abstract |
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In the last few years, a spectrum of dendritic cells(DCs), including toll like receptors(TLRs), might play a critical role in regulating allergy and asthma. DC plays a central role in initiating immune responses, linking innate and adaptive responses to pathogen. Human peripheral blood has three non- overlapping dendritic subset that expressed various 11 TLRs. These dendritic subsets and TLR contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. A better understanding of DC immunobiology may lead to the comprehension of allergy pathophysiology to prevent early stage allergic march |
| Key Words:
Toll like receptor, Plasmacytoid dendritic cell, Myeloid dendritic cell, Th1/Th2 deviation |
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