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A Neonatal Case of Symptomatic Congenital Cytomegalovirus Infection with Hearing Defect

Journal of the Korean Pediatric Society 2001;44(2):205-210.
Published online February 15, 2001.
A Neonatal Case of Symptomatic Congenital Cytomegalovirus Infection with Hearing Defect
Sung Jun Jang, Yoon Jung Cho, Sang Lak Lee, Joon Sik Kim, Tae Chan Kwon
Department of Pediatrics, School of Medicine, Keimyung University, Taegu, Korea
청력 장애가 동반된 유증상 선천성 거대세포바이러스 감염 신생아 1례
장성준, 조윤정, 이상락, 김준식, 권태찬
계명대학교 의과대학 소아과학교실
Abstract
Cytomegalovirus(CMV) is one of the leading cause of intrauterine infections of man with an incidence ranging from 0.48% to 2.2% of all live births. Although the majority of CMV-infected newborns are clinically asymptomatic at birth, some will have signs of congenital infection : Intrauterine growth retardation, petechial or purpuric rash, microcephaly, anemia, thrombocytopenia, jaundice, hepatosplenomegaly and intracranial calcification. We experienced a case of symptomatic congenital CMV infection in a 1-day-old male who presented generalized petechiae, hepatosplenomegaly, anemia, thrombocytopenia. Urine PCR and viral culture for CMV were positive, and a brain CT revealed ventriculomegaly and periventricular calcification. And auditory evoked potential revealed left sensorineural hearing loss. He received ganciclovir treatment for 6 weeks, was discharged in good health, and continued conunder follow-up at the outpatient department.
Key Words: CMV infection, Hearing loss, Newborn


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