Journal of the Korean Pediatric Society 2000;43(12):1583-1590.
Published online December 15, 2000.
High-Resolution Computed Tomography(HRCT) Findings of the Lung in Asthmatic Children and Their Correlation with Clinical Characteristics
Do Kyun Kim1, Yang Park1, Young Yull Koh1, Jung Eun Chun2, Woo Sun Kim2
1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
2Department of Radiology, College of Medicine, Seoul National University, Seoul, Korea
기관지 천식 환아에서 흉부 고해상 CT 소견과 임상적 특성과의 관련성
김도균1, 박 양1, 고영률1, 천정은2, 김우선2
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 방사선과학교실
: The purposes of this study were to determine the abnormal high-resolution computed tomography(HRCT) findings of the lung in uncomplicated asthmatic children, to compare the clinical characteristics between normal and abnormal HRCT finding groups and to correlate abnormal HRCT findings with clinical characteristics, especially FEV1 and PC20.
: Forty asthmatic children were studied. Inspiratory and expiratory HRCT scans were performed on all patients. Pulmonary function tests and methacholine challenge tests were done and total eosinophil counts and total IgE level were checked during the symptom-free period. According to the presence of abnormality in HRCT findings, the subjects were divided into two groups : Normal and abnormal HRCT finding group. Clinical characteristics, severity of asthma, FEV1 and PC20 were compared between the two groups.
: Abnormal HRCT findings were air trapping, fibrosis, bronchial dilatation, and bronchial wall thickening. Air trapping was the most prevalent finding(50%). Significant differences in total IgE level(P<0.05), severity of asthma(P<0.05), FEV1(P<0.05) and PC20(P<0.05) were found between patients with abnormal HRCT findings and those with normal HRCT findings. Air trapping scores were significantly correlated with FEV1(r=-0.469, P<0.05) and PC20(r=-0.315, P<0.05).
: Air trapping was detected in 50% of uncomplicated asthmatic children and air trapping scores were correlated well with the extent of airflow obstruction and the degree of airway hyperresponsiveness. Our data suggest that the extent of air trapping found on HRCT scans reflects the severity of asthma and airway hyperresponsiveness in asthmatic patients.
Key Words: Childhood asthma, High-resolution computed tomography, Air trapping

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