| A Case of Severe Hypertensive Pulmonary Edema Associated
with Neuroblastoma during Chemotherapy |
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Hee Suk Cho1, Hwang Min Kim1, Seok Won Park1, Jong Soo Kim1, Yoon Mi Kim2, Kwang Kil Lee2 |
1Department of Pediatrics, College of Medicine, Yonsei University Wonju, Wonju, Korea
2Department of Pediatrics and Pathology, College of Medicine, Yonsei University Wonju, Wonju, Korea |
| 항암화학요법 도중 고혈압성 폐부종이 병발한 신경모세포종 1례 |
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조희숙1, 김황민1, 박석원1, 김종수1, 김윤미2, 이광길2 |
1연세대학교 원주의과대학 소아과학교실
2연세대학교 원주의과대학 병리학교실 |
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| Abstract |
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The authors report a 7-year-old boy with neuroblastoma complicated by severe hypertension and pulmonary edema. Abdominal computed tomographic scan revealed a huge mass surrounding the aorta. After administration of cancer treatment, there was a marked increase in serum catecholamines level and hypertension, which resulted in pulmonary edema and heart failure. Alpha adrenergic blocking agents(prazocin, terazocin) were administrated, successfully controlling the hypertension. The tumor differentiated to ganglioneuroblastoma after chemotherapy. The catecholamine production of the residual neuroblastoma must have increased because the treatment induced differentiation. It is important to watch for the development of hypertension during the treatment of neuroblastoma. |
| Key Words:
Neuroblastoma, Hypertension, Pulmonary edema, Catecholamine, Chemotherapy, Differentiation |
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