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Implication of vacA s1 Genotype of Helicobacter pylori in Children

Journal of the Korean Pediatric Society 1999;42(11):1516-1523.
Published online November 15, 1999.
Implication of vacA s1 Genotype of Helicobacter pylori in Children
Yae Jean Kim1, Hae Young Park2, Mi Ae Lee3, Jeong Wan Seo1
1Department of Pediatrics, Ewha Womans University, College of Medicine, Seoul, Korea
2Department of Biochemistry, Ewha Womans University, College of Medicine, Seoul, Korea
3Department of Clinical Pathology, Ewha Womans University, College of Medicine, Seoul, Korea
Helicobacter pylori 위염 소아에서 vacA s1유전형의 의의
김예진1, 박혜영2, 이미애3, 서정완1
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 생화학교실
3이화여자대학교 의과대학 임상병리학교실
Correspondence: 
Jeong Wan Seo, Email: 1
Abstract
Purpose
: Recently vacA s1 genotype of Helicobacter pylori was known to be associated with enhanced inflammation and peptic ulceration. To evaluate the association of the vacA s1 genotype with enhanced inflammation and peptic ulceration in children, we performed a polymerase chain reaction(PCR) for vacA s1 genotype.
Methods
: Twenty-seven CLO test-positive children were enrolled. They also revealed histological detection of bacteria and positive ureC gene by PCR in gastric biopsy specimens. The vacA s1, s2 and cagA genotypes were assayed by PCR in gastric biopsy specimens.
Results
: There were no association between vacA s1 genotype with peptic ulceration, severe inflammatory reaction, histological density of H. pylori, and formation of lymphoid follicle. None of our patients showed intestinal metaplasia. The vacA s1 genotype with or without cagA gene was not associated with peptic ulceration and enhanced inflammation.
Conclusion
: This study suggested that vacA s1 genotype of H. pylori was not associated with peptic ulceration and enhanced inflammation in Korean children.
Key Words: Helicobactoer pylori, vacA s1, cagA, Children


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