| Effects of Patent Ductus Arteriosus on Right Ventricle in
Premature Infants : by M-mode and Doppler Echocardiography |
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Eun Jeung Kim, Eun Sil Lee, Young Hwan Lee, Son Moon Shin, Jeong Ok Hah |
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Department of Pediatrics, School of Medicine, Yeungnam University, Taegu, Korea |
| 미숙아의 동맥관 개존이 우심실에 미치는 영향 :도플러 심초음파도를 이용한 연구 |
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김은정, 이은실, 이영환, 신손문, 하정옥 |
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영남대학교 의과대학 소아과학교실 |
Correspondence:
Eun Sil Lee, Email: 1
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| Abstract |
Purpose
: Patent ductus arteriosus, derived left to right shunt flows, elevate the pulmonary artery
pressure in infants and children and may alter right ventricular afterload thereby right ventricular
function. Therefore, we examined the effects of patent ductus arteriosus on the right ventricular
systolic time interval in premature infants by non-invasive Doppler echocardiography.
Methods
: Tweleve premature infants with patent ductus arteriosus were studied by M-mode and
Doppler echocardiography before and after treatment with mefenamic acid. Heart rate(HR), ratio of
left atrium/aorta(LA/AO), right ventricular preejection period (RVPEP), right ventricular ejection
time(RVET) and right ventricular systolic time interval(RVSTI : ratio of RVPEP/RVET), both
corrected or uncorrected for heart rate were measured.
Results
: After mefenamic acid treatment, in infants showing clinical response, right ventricular
preejection period(RVPEP) and right ventricular systolic time intetrval(RVSTI), both corrected or
uncorrected for heart rate, decreased significantly following ductal closure(RVPEP : 70.3msecc¡¾14.5
vs 54.3msec¡¾10.9, P < 0.01, RVPEPc : 129.2msec¡¾13.5 vs 111.7msec¡¾8.4, P < 0.01, RVSTI : 0.38¡¾0.09 vs
0.28¡¾0.05, P < 0.05, RVSTIc : 0.31¡¾0.04 vs 0.27¡¾0.03, P < 0.01).
Conclusion
: Premature infants with patent ductus arteriosus exhibit echocardiographic evidence of
increased RVSTI as a result of increased right ventricular afterload. This results suggest that we
have to make every effort to prevent the ductal reopening or early closure of ductus arteriosus in
premature infants. |
| Key Words:
Right ventricular systolic time interval, Patent ductus arteriosus, Premature infants |
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