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A Clinical and Histological Study of Allergic Colitis in Infant

Journal of the Korean Pediatric Society 1998;41(4):521-528.
Published online April 15, 1998.
A Clinical and Histological Study of Allergic Colitis in Infant
Jae Bok Kim1, Kyung Mo Kim1, Ki Soo Kim1, Soo Young Pi1, Yang Soon Park2
1Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Department of Diagnostic Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
영아 알레르기성 대장염의 임상 및 병리학적 고찰
김재복1, 김경모1, 김기수1, 피수영1, 박양순2
1울산대학교 의과대학 소아과학교실
2울산대학교 의과대학 진단병리학교실
Correspondence: 
Kyung Mo Kim, Email: 1
Abstract
Purpose
: This study was done to evaluate the clinical and pathologic aspects of allergic colitis.
Methods
: This study evaluated 19 infants who presented with fresh blood mixed stools. Limited colonoscopy and biopsy were performed. Among the 19 infants, 13 infants were diagnosed as allergic colitis by histological findings. We analyzed the clinical and histological characteristics of 13 infants.
Results
: Male and female were 8 and 5 respectively. The mean age of the infants was 3 months(4 days to 12 months). Major symptoms were rectal bleeding(13), mucoid stool(6), diarrhea(5), vomiting(2). Feedings before diagnosis were breast milk(3), formula milk(4), formula and breast milk(5), and weaning diet(1). In labortory data, anemia(2) and eosinophilia(12) were found in some infants. Endoscopic findings were focal erythema(7), nodularity(1), erythema and nodularity(4), hemorrhage(1). Histopathologic finding was eosinophilic infiltration in lamina propria with preserved mucosal architecture in all. In addition, cryptitis(13), lymphoid follicular hyperplasia(7), crypt abscess(1) were also observed. All the infants improved with cessation of rectal bleeding and diarrhea within three days after dietary change.
Conclusion
: Allergic colitis should be considered as one of the major cause of rectal bleeding in healthy appearing infants. Limited colonoscopy and biopsy should be considered in establishing a definitive diagnosis.
Key Words: Allergic colitis, Eosinophilic colitis, Infant, Rectal bleeding, Colonoscopy


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