High Frequency Oscillatory Ventilation as a Rescue Therapy of Severe Neonatal Respiratory Failure |
Eun Kyung Lee, Yun Sil Chang, Won Soon Park |
Department of pediatrics, College of Medicine, Sung Kyun Kwan University, Samsung Medical Centerm Seoul, Korea |
심한 신생아 호흡부전에서 고빈도 진동성 인공환기요법의 치료효과 |
이은경, 장윤실, 박원순 |
성균관대학교 의과대학 삼성서울병원 소아과 |
Correspondence:
Eun Kyung Lee, Tel: +82.2-3468-3107, Fax: +82.2-558-1119, |
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Abstract |
Purpose : High frequency oscillatory ventilation(HFOV) using suprathysiologic ventilatory frequency is a new therapeutic technique, which has a improved survival and reduced complication of newborn infants suffering from severe respiratory failure. The aim of this study was to assess the efficacy of HFOV as a rescue therapy for infants with severe respiratory failure and to compare the treatment results of several types of respiratory diseases.
Methods : Retrospective analysis of the medical records of neonates who were admitted due to severe respiratory failure, they had an arterio-alveolar oxygen tension ratio below 0.25 despite of conventional mechanical venrilation.
Results : twenty-two neonates(survivor group 15, nonsurvivor group 7) were evaluated. HFOV treatment was initianted at 4.0¡¾4.6 days after birth in survivor group, and 4.4¡¾3.1 days in nonsurvivor group. Plmonary hemorrhage and airleak syndrome is the most common indication of HFOV. The highest survival rate was 75.0% in homogenous lung diseases. The oxygenation index after 12 hours and a/APO2 after 6 hours on HFOV were significantly higher in those infants who survived, compared to those who died(P<0.05). The complications after HFOV were pneumothorax(survivor group 1, nonsurvivor group 3) and bronchopulmonary dyslasia(survivr group 5 nonsurvivor group 2).
Conclusion : We concluded that high frequency oscillatiory ventilation significantly improves oxygenation in neonates with severe pulmonary disease, who did not respond to conventional mechanical cenrilator therapy, and is useful as a rescue therapy in severe neonetal respiratory failure. |
Key Words:
High frequency oscillatory ventilation, Neomate, Respiratory failure |
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