| Immunohistochemical Study of Bcl-2 Oncoprotein Expression in Childhood Non-Hodgkin's Lymphoma |
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Sung Mee Kim1, Jin Hwa Jung1, Jeong Ho Lee1, Jong Dae Jo1, Young Tak Lim2, Do Youn Park3, Sun Kyeung Lee3 |
1Department of Pediatrics, Marynoll Hosipital, Pusan, Korea
2Department of Pediatrics, Pusan National University, Pusan, Korea
3Department of Pathology, Pusan National University, Pusan, Korea |
| 소아의 비 Hodgkin 림프종에서 Bcl-2 암단백 발현의 면역조직화학적 연구 |
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김성미1, 정진화1, 이정호1, 조종대1, 임영탁2, 박도윤3, 이선경3 |
1부산 메리놀병원 소아과
2부산대학교 의과대학 소아과학교실
3부산대학교 의과대학 병리학교실 |
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| Abstract |
Purpose
: The aim of the present study was to assess the clinicopatholgical significance
of Bcl-2 oncoprotein expression in childhood non-Hodgkin' s lymphoma(NHL).
Methods
: We have assessed 16 cases of childhood NHL during last 6 years from
1990 to 1995. Bcl-2 oncoprotein expression has been semiquantitatively analyzed in
paraffin sections from 16 cases of childhood NHL with 39 control cases of adult NHL.
The expression of Bcl-2 oncoprotein was correlated with histologic grade, immunophenotype,
proliferative activity as measured by immunostain of Ki-67 antigen, clinical
stage, and survival rate(event free survival rate, EFS).
Results
:
1) Bcl-2 oncoprotein expression significantly decreased according to increase of
histological grade(P < 0.05).
2) High Bcl-2 oncoprotein expression was more frequent in B-cell NHL than T-cell
NHL(P < 0.05).
3) Proliferative activity as measured by immunostain of Ki-67 antigen was negatively
correlated with Bcl-2 oncoprotein expression(P < 0.05).
4) Bcl-2 oncoprotein expression was not correlated with clinical stage(P > 0.05).
5) EFS of patients was significantly correlated with Bcl-2 oncoprotein expression, that
is, reduced EFS was demonstrated in the patients with low Bcl-2 oncoprotein expression
(P < 0.05).
Conclusions
: Thus Bcl-2 oncoprotein, as demonstrated immunohistochemically in
routinely paraffin embedded tissue, can be restrictively used in prediction of prognosis
and grade of childhood NHL, in aggrement with the role of Bcl-2 oncoprotein in blocking
of apoptosis and indirect contribution to increase of cellular proliferative activity of NHL. |
| Key Words:
Bcl-2 oncoprotein, Non-Hodgkin’s Lymphoma, Children |
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