| Analgetic Effect of Chloral Hydrate in Pain Induced by Spinal Tap in Neonates |
|
Eun Jin Choi, Heng Mi Kim |
|
Department of Pediatrics, Kyungpook National University School of Medicine, Taegu, Korea |
| 신생아 뇌척수액 천자전 Chloral Hydrate 투여가 통증 반응에 미치는 영향 |
|
최은진, 김행미 |
|
경북대학교 의과대학 소아과학교실 |
|
|
|
|
| Abstract |
Purpose
: The need for analgesia in neonates during and after surgery has been
widely accepted in the past decade. Pain relief and sedation are still rarely used during
minor treatment procedures in the neonatal intensive care units. However, many
diagnostic and treatment procedures in the neonatal intensive care unit are noxious and
often painful, and highly stressful for sick neonates.
Methods
: A prospective randomized clinical trial of chloral hydrate sedation in 18
neonates who received spinal tap as a routine laboratory examination for sepsis was
conducted. About one hour prior to the procedure, neonates were administered 50mg/kg
of chloral hydrate intrarectally. Neonates were monitored for changes of heart rate, O2
saturation, pain score. Plasma β-endorphin level was evaluated one hour before and after
the procedure. Neonates in both groups were full-term with appropriate birth weight for
their gestational age. Age on study was 7±3 days in chloral hydrate group and 15±10
days in control group.
Results
: β-endorphin level before and after procedure in chloral hydrate group was
3.15±0.68pmol/L and 3.6±0.81pmol/L prospectively. β-endorphin level before and after
procedure in control group was 3.44±0.68pmol/L and 2.94±0.57pmol/L prospectively. There
were no significant changes between before and after in both groups, between chloral
hydrate and control group.
Pain score was higher in control group(9.6±2.7 vs 5.7±2.8 p< 0.05) but incidence of
hypoxic episode revealed no significant differences between chloral hydrate and control
group.
Conclusion
: The use of chloral hydrate for neonates seems not effective in reducing
pain reaction associated with spinal tap. |
| Key Words:
Analgesia, Chloral hydrate, β-endorphin, Pain score, Hypoxic episode |
|
PDF Links
Download Citation
