Journal of the Korean Pediatric Society 1997;40(7):925-930.
Published online July 15, 1997.
Analgetic Effect of Chloral Hydrate in Pain Induced by Spinal Tap in Neonates
Eun Jin Choi, Heng Mi Kim
Department of Pediatrics, Kyungpook National University School of Medicine, Taegu, Korea
신생아 뇌척수액 천자전 Chloral Hydrate 투여가 통증 반응에 미치는 영향
최은진, 김행미
경북대학교 의과대학 소아과학교실
: The need for analgesia in neonates during and after surgery has been widely accepted in the past decade. Pain relief and sedation are still rarely used during minor treatment procedures in the neonatal intensive care units. However, many diagnostic and treatment procedures in the neonatal intensive care unit are noxious and often painful, and highly stressful for sick neonates.
: A prospective randomized clinical trial of chloral hydrate sedation in 18 neonates who received spinal tap as a routine laboratory examination for sepsis was conducted. About one hour prior to the procedure, neonates were administered 50mg/kg of chloral hydrate intrarectally. Neonates were monitored for changes of heart rate, O2 saturation, pain score. Plasma β-endorphin level was evaluated one hour before and after the procedure. Neonates in both groups were full-term with appropriate birth weight for their gestational age. Age on study was 7±3 days in chloral hydrate group and 15±10 days in control group.
: β-endorphin level before and after procedure in chloral hydrate group was 3.15±0.68pmol/L and 3.6±0.81pmol/L prospectively. β-endorphin level before and after procedure in control group was 3.44±0.68pmol/L and 2.94±0.57pmol/L prospectively. There were no significant changes between before and after in both groups, between chloral hydrate and control group. Pain score was higher in control group(9.6±2.7 vs 5.7±2.8 p< 0.05) but incidence of hypoxic episode revealed no significant differences between chloral hydrate and control group.
: The use of chloral hydrate for neonates seems not effective in reducing pain reaction associated with spinal tap.
Key Words: Analgesia, Chloral hydrate, β-endorphin, Pain score, Hypoxic episode

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