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Histologic Study of Helicobacter pylori-Associated Gastritis in Children

Journal of the Korean Pediatric Society 1996;39(6):811-821.
Published online June 15, 1996.
Histologic Study of Helicobacter pylori-Associated Gastritis in Children
Jeong Wan Seo1, Woon Sup Han2
1Department of Pediatrics, Ewha Womans University, College of Medicine, Korea
2Department of Pathology, Ewha Womans University, College of Medicine, Korea
소아 Helicobacter pylori 위염의 조직학적 연구
서정완1, 한운섭2
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 병리학교실
Abstract
Purpose
: The aim of the present study was to assess the clinical, endoscopic and histologic findings of the Helicobacter pylori(Hp)-associated gastritis in children.
Methods
: We have assessed 91 patient(age range 3-15 years) referred for upper intestinal endoscopy during 17 months. At least two antral biopsies were taken during endoscopy. The histological analysis and CLO test were done. The histologic changes were scored and semiquantitative assessment of the degree of Hp colonization was performed using Giemsa' stain.
Results
: 1) Helicobacter pylori(Hp) was detected by CLO test and/or histologic analysis in 35 patients(38.5%). The CLO test was positive in 25 cases and H.pylori was colonized histologically in 10 patients. 2) The clinical symptoms were not significantly different between Hp positive and Hp negative patients(p>0.01). 3) Nodular antritis(37.1%) was a frequent endoscopic finding in Hp-infected patients, particularly in the subgroup with active chronic gastritis(93.8%). All patient with nodular antritis had Hp infection. 4) Helicobacter pylori has been associated both with active chronic gastritis(42.9%) and with nonactive chronic gastritis(40.0%). The common abnormal histologic finding was active chronic gastritis(42.9%) in Hp positive patients and nonactive chronic gastritis(66%) in HP negativepatients. A significant correlation was found between Hp colonization score and the histologic categories(p<0.01). 5) ThefrequencyofHpinfection(positiveness)asrelatedtohistologiccategorieswas: active chronic gastritis 93.8 %;duodenalulcer66.7%;gastric ulcer33.3 %;nonactive chronicgastritis27.5%;normal16.7%. 6) The histolgical colonization by Hp was assessed semiquantitatively, and a significantly greater Hp colonization score was observed in patients with signs of histological activity(p<0.01).
Conclusion
: This study suggests that Hp infection was significantly associated with endoscopic nodular antritis and the presence of gastroduodenalpathology.
Key Words: Helicobacter pylori, Gastritis, Children, Histology


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