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A Case of Carbamazepine-Induced Toxic Epidermal Necrolysis

Journal of the Korean Pediatric Society 1993;36(11):1630-1634.
Published online November 15, 1993.
A Case of Carbamazepine-Induced Toxic Epidermal Necrolysis
Gi Chan Na, Kyung Seok Kim, Eun Gyeoung Jung, Kyyng Rae Moon, Sang Kee Park, Yeoung Bong Park
Department of Pediatrics, Collefge of Medicine, Chosun University, Kwang Jum Korea
Carbamazepine에 의한 중독성 표피괴사 융해증 1례
나기찬, 김경석, 정은경, 문경래, 박상기, 박영봉
조선대학교 의과대학 소아과학교실
Abstract
Drug-induced toxic epidermal necrolysis (TEN) is a bullous erythematous disease that is characterized by the appearance of scaled lesions and large sheets of pilling on the skin. A case of TEN occured in a 10 month old female patient. The characteristic skin lesions of TEN developed after oral administration of carbamazepine for a partial seizure. Thig case consists of prodrome of malaise, fever, anorexia, and conjunctivity followed by erythema & flaccid bullae formation. Diagnosis was confirmed by histologic findings. This patient was treated with a massive systemic corticosteroid, antibiotics, fluid and electrolytes, and topical measures. Authors experienced an extermely rare case of TEN due to carbamazepine, So report it with a brief review of literature.
Key Words: Carbamazepine, Toxic Epidermal Necrolysis


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