Journal of the Korean Pediatric Society 1992;35(5):614-620.
Published online May 15, 1992.
Hepaplastin Test for Screen of Vitamin K Deficiency in Term and Preterm Neonates
Eun Mi Kim, Gyung Og Yu, Dong Rak Choi, Chong Young Park, Hae Ran Lee, Choon Myung Ro
Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
만삭아와 미숙아에서 비타민 K결핍증 예방을 위한 Hepaplastin검사 비교 연구
김은미, 유경옥, 최동락, 박종영, 이혜란, 노준명
한림대학교 의과대학 소아과학교실
To screen vitamin K deficiency in term and preterm neonates, the authors conducted Hepaplastin test based on 40 term and 40 preterm neonates who were delivered at Han Gang Sacred Heart Hospital. Also we compared Hepaplastin activity of term neonates with that of preterm neonates. 0.5mg or 1mg of vitamin K1 was injected intramuscularly immediately after birth according to the birth weight, and hepaplastin test was performed the 3rd day and the 1st month of life. The results were as follows: 1) The Hepaplastin activity of 1-month-old infants was significantly reduced comparing with that of the term neonates. 2) The Hepaplastin activity of 3-day-old preterm infants was significantly reduced comparing with that of the term neonates. 3) As for the Hepaplastin activity of 1-month-old infants, there was no significant difference in both term and preterm neonates. 4) The frequency of Hepaplastin activity below 35% was more prevalent in preterm than in term neonates, and thd Hepaplastin activity was significantly increased after readministration of vitamin K1 in both groups.
Key Words: Hepaplastin Activity, Vitamin K Deficiency

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