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Original Article

Hepatitis B Virus Precore and Core Promotor Mutations in Children with Chronic Hepatitis B Infection

Woo Yeong Chung, Jin Kuk Kim, Yeong Hoon Kim, Yeong Hong Park, Chul Ho Kim

Clin Exp Pediatr. 1999;42(10):1392-1402. Published online October 15, 1999

Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 31 children with chronic HBV infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Twenty-nine adr type were analyzed. The mutations...

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