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"Most viewed" Articles are from the articles published in 2022 during the last six month.
- Letter to the Editor
- Infection
- Changes in epidemiology of parainfluenza virus and respiratory syncytial virus infection during coronavirus disease 2019 pandemic in Korea (779 times)
- Kyung-Ran Kim, Hwanhee Park, Doo Ri Kim, Yae-Jean Kim
- Clin Exp Pediatr. 2022;65(6):320-321. Published online March 10, 2022
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Question: How the epidemiology of other childhood respiratory viruses has changed during coronavirus disease 2019 (COVID-19) in Korea?
Finding: Parainfluenza virus (PIV) typically circulated in the spring, and respiratory syncytial virus (RSV) epidemic started in autumn in Korea before COVID-19 pandemic. PIV and RSV seasons disappeared in 2020 and came back in 2021 with atypical seasonality. PIV season was changed from spring to autumn, and the beginning of RSV season was slightly delayed from autumn to early winter in 2021.
Meaning: Circulation of PIV and RSV was changed to unusual seasons and patterns during COVID-19 pandemic period.
- Clinical Note
- Genetics and Metabolism
- Biallelic POLR3A variants cause Wiedemann-Rautenstrauch syndrome with atypical brain involvement (777 times)
- Byungseung Moon, Minhye Kim, Hye Jin Kim, Jae So Cho, Hey Joon Son, Byung Chan Lim, Ki Joong Kim, Jong Hee Chae, Soo Yeon Kim
- Clin Exp Pediatr. 2023;66(3):142-144. Published online December 30, 2022
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- Review Article
- Gastroenterology
- Clinical importance of immunonutrition in infants: a review of the recent literature (773 times)
- Ji Sook Park
- Clin Exp Pediatr. 2022;65(7):337-343. Published online February 17, 2022
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Nutrients are important in the developing immune system. Human milk supplies diverse bioactives to prevent acute infection or chronic inflammation. Immunoglobulins, lactoferrin, and glutamine in human milk decrease gastrointestinal and respiratory infection. Human milk oligosaccharides promote the growth of intestinal microbiota, the gut barrier, and antimicrobial or antiviral activity. Micronutrients act as anti-inflammatory immunonutrients, too. However, the toxicity of some nutrients from an overdose should be considered.
- Neonatology (Perinatology)
- Updates in neonatal resuscitation: routine use of laryngeal masks as an alternative to face masks (745 times)
- Eun Song Song, Ga Won Jeon
- Clin Exp Pediatr. 2024;67(5):240-246. Published online July 11, 2023
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In neonatal resuscitation:
· Laryngeal masks are recommended when endotracheal intubation or positive-pressure ventilation fails.
· Laryngeal masks are useful even during chest compressions.
· Laryngeal masks aid neonates >34 weeks’ gestation and/or with a birth weight >2 kg.
· Main usage barriers include limited experience (81%), preference for endotracheal tubes (57%), and lack of awareness (56%).
· Second-generation laryngeal masks have a built-in esophageal drainage tube that prevents regurgitation into the glottis, and an orogastric tube can be inserted within the esophageal drainage tube to protect against gastric inflation.
- Original Article
- Cardiology
- Echocardiographic reference z scores of right ventricular dimension and systolic function of children aged 5–12 years (737 times)
- Alaba Busola Oladimeji, Moriam Omolola Lamina, Peter Odion Ubuane, Motunrayo Oluwabukola Adekunle, Omolara Adeolu Kehinde, Barakat Adeola Animasahun, Olisamedua FidelisNjokanma
- Clin Exp Pediatr. 2023;66(5):215-222. Published online April 18, 2023
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Question: Z score reference values for right ventricular size and systolic function in children using echocardiography are available in several countries. Despite the high burden of diseases involving the right ventricle in Nigeria, these reference values have limited applicability.
Finding: The right ventricular sizes of Nigerian children differed from those published elsewhere.
Meaning: These reference values will aid the treatment, monitoring, and pre- and postintervention for Nigerian children.
- Review Article
- Neonatology (Perinatology)
- Neonatal seizures: stepping outside the comfort zone (731 times)
- Menna Hashish, Mohamed Reda Bassiouny
- Clin Exp Pediatr. 2022;65(11):521-528. Published online April 4, 2022
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· Use conventional and amplitude-integrated electroencephalography to confirm clinical seizures and screen high-risk newborns.
· Select an explicit clear elective event to be treated with less toxic and more effective antiepileptics.
- Other
- Children’s health affected by parent’s behavioral characteristics: a review (730 times)
- Sung Eun Kim, Jongin Lee
- Clin Exp Pediatr. 2024;67(5):232-239. Published online August 21, 2023
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· Parents’ occupational hazards, long working hours, and smoking behaviors should be modified adequately to minimize adverse health effects on their children.
· As of 2023, several diseases from fetal exposure to occupational hazards can be compensated with Industrial Accident Compensation Insurance in South Korea.
· A directed acyclic graph is recommended for medical research to control the effects of parents’ behaviors on children’s health.
- Letter to the Editor
- Cardiology
- Early prophylaxis of cardiomyopathy with beta-blockers and angiotensin receptor blockers in patients with Duchenne muscular dystrophy (729 times)
- Heirim Lee, Jinyoung Song, I-Seok Kang, June Huh, Jin A Yoon, Yong Beom Shin
- Clin Exp Pediatr. 2022;65(10):507-509. Published online August 22, 2022
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- Original Article
- Infection
- Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature (723 times)
- Abdulrasheed Usman, Muhammad Hamis Musa, Bukhari Isah Shuaib, Olayemi Balogun, Mukhtar Adeiza
- Clin Exp Pediatr. 2023;66(7):307-316. Published online December 22, 2022
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The peripartum period is an important transmission time for human T-cell lymphotropic virus-1 (HTLV-1) infection, mainly via breastfeeding and partly through the placental tissues of carrier mothers. Although most HTLV-1–infected individuals are asymptomatic, fetal and childhood infections often result in several diseases with disappointing treatment outcomes. An estimated HTLV-1 burden in Nigeria among perinatal women must be determined to enable rational planning of a comprehensive health care intervention.
- Neonatology (Perinatology)
- Is fetal nuchal cord associated with autism spectrum disorder? A meta-analysis (717 times)
- Ensiyeh Jenabi, Maryam Ahmadi, Azam Maleki
- Clin Exp Pediatr. 2022;65(3):131-135. Published online September 24, 2021
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Question: Is fetal nuchal cord a risk factor for autism spectrum disorder (ASD)?
Finding: Five articles (1 cohort, 4 case-control; total 3,088 children) were included in the present meta-analysis. Fetal nuchal cord was not a risk factor for ASD (odds ratio, 1.11; 95% confidence interval, 0.66–1.57). There was homogeneity among studies that reported a risk of ASD (I2=0.0).
Meaning: Fetal nuchal cord is not a risk factor for ASD.
- Gastroenterology
- Association between maternal weight gain during pregnancy and child’s body mass index at preschool age (717 times)
- Jeewon Shin, Yoowon Kwon, Ju Hee Kim, Su Jin Jeong
- Clin Exp Pediatr. 2023;66(2):76-81. Published online November 30, 2022
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Question: What are the risk factors of newborn birth weight? Does gestational weight gain and prepregnancy body mass index affect childhood weight?
Finding: Excess maternal weight gain increases the risk of overweight/obesity, newborn birth weight, and child body mass index at 4–6 years.
Meaning: Maternal weight control before and during pregnancy should be well controlled.
- Letter to the Editor
- Endocrinology
- Accuracy of predicted adult height using the Greulich-Pyle method and artificial intelligence medical device (708 times)
- Dongho Cho, Yun Sun Choi, Hayun Oh, Young min Ahn, Ji-Young Seo
- Clin Exp Pediatr. 2023;66(3):145-147. Published online January 25, 2023
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- Original Article
- Developmental and Behavioral Medicine
- Neonatal risk factors associated with attention-deficit/hyperactivity disorder: an umbrella review (705 times)
- Ensiyeh Jenabi, Erfan Ayubi, Sajjad Farashi, Saeid Bashirian, Fereshteh Mehri
- Clin Exp Pediatr. 2023;66(10):441-446. Published online July 14, 2023
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Question: The risk factors for attention deficit hyperactivity disorder (ADHD), such as breastfeeding, congenital heart disease, and low birth weight, in neonates are not well understood.
Finding: This umbrella review obtained significant effect sizes for ADHD for congenital heart disease (odds ratio [OR], 3.04), low birth weight (OR, 2.25), never breastfed (OR, 1.55), and Apgar score (OR, 1.30).
Meaning: Congenital heart disease, low birth weight, lack of breastfeeding, and Apgar scores were significant factors for ADHD.
- Perspective
- Infection
- Statement on healthcare system preparedness in response to COVID-19 Omicron subvariants BA.4 and BA.5 surge in Korea from the Korean Pediatric Society and Korean Society of Pediatric Infectious Diseases (703 times)
- Eun Young Cho, Dong Hyun Kim, Soo-Han Choi, Ki Wook Yun, Jong Gyun Ahn, Hye-Kyung Cho, Hyunju Lee, Jina Lee, Taek-Jin Lee, Byung-Wook Eun, Jin Lee, Dae Sun Jo, Yun-Kyung Kim, Yae-Jean Kim; Committee on Infectious Diseases of the Korean Pediatric Society
- Clin Exp Pediatr. 2022;65(11):510-511. Published online September 23, 2022
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In order to respond to the recent surge in coronavirus disease 2019 (COVID-19) cases and the continuously changing epidemiology of COVID-19, a sustainable and flexible pediatric healthcare system must be prepared considering the specificity of pediatric care. We demand a more proactive response from the health authorities to check the current state of pediatric COVID-19 patient care and to ensure that pediatric patients receive appropriate and timely management.
- Review Article
- Neonatology (Perinatology)
- Growth patterns of preterm infants in Korea (701 times)
- Joohee Lim, So Jin Yoon, Soon Min Lee
- Clin Exp Pediatr. 2022;65(1):1-9. Published online July 8, 2021
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∙ The growth of preterm infants is a main focus of neonatology.
∙ Preterm infants in Korea, especially those with a very low birth weight, achieve retarded growth.
∙ Careful growth monitoring and early intervention will contribute to better development outcomes and quality of life for preterm infants and improve public health.
- Letter to the Editor
- Oncology
- Retrospective review of severe acute respiratory syndrome coronavirus-2 infection in children with acute leukemia from a tertiary care hospital in Northern India (679 times)
- Suhail Chhabra, Aditya Dabas, Richa Mittal, Neha Goel, Ritabrata Roy Chowdhary, Satyendra Batra, Amitabh Singh, Rani Gera
- Clin Exp Pediatr. 2022;65(3):150-151. Published online November 26, 2021
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- Review Article
- Cardiology
- Environmental changes surrounding congenital heart disease (671 times)
- Eun-Young Choi
- Clin Exp Pediatr. 2023;66(8):332-338. Published online January 2, 2023
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· As the number of patients with congenital heart disease increases, the medical burden increases.
· Various fusion imaging techniques using percutaneous procedures have been introduced.
· With advances in technology, convenient ambulatory devices have been introduced.
· A well-organized team approach is required to resolve advanced heart failure in patients with congenital heart disease.
- Editorial
- Immunology
- Systemic autoinflammatory disorders: autoinflammatory and autoimmune disorders (671 times)
- Young Dae Kim
- Clin Exp Pediatr. 2023;66(10):439-440. Published online July 4, 2023
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· Systemic autoinflammatory disorders (SAIDs) typically have an early onset in life, and may have close relatives may have similar disease.
· SAIDs should be suspected in any patient, especially children, who experience persistent or recurrent inflammatory episodes that fail to fit the pattern of other established diseases.
· Advancements in the understanding of autoinflammation will provide novel diagnostic and therapeutic options for SAIDs patients.
- Emergency Medicine
- Current diagnosis and image-guided reduction for intussusception in children: teamwork approach (661 times)
- Ji-Hyun Seo
- Clin Exp Pediatr. 2023;66(2):66-67. Published online September 1, 2022
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· The successful and safe enema reduction of intussusception depends primarily on the experience and preference of the radiologists and the availability of resources.
· The establishment of a standardized manual or protocol for reduction and pre-reduction treatment of intussusception, along with the collaboration of pediatricians, radiologists, and surgeons, is expected to improve the treatment success rate.
- Original Article
- Developmental and Behavioral Medicine
- Parenting stress and interactive engagement behaviors in children with developmental delay (661 times)
- Jung Sook Yeom, Rock Bum Kim, Jae Young Cho, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Hyang-Ok Woo
- Clin Exp Pediatr. 2023;66(6):252-261. Published online May 19, 2023
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· Question: What level of parenting stress is experienced by parents of children with developmental delays (DDs) without autism spectrum disorder, and what factors contribute to it?
· Findings: Parents of children with DDs experienced high parenting stress that were significantly mediated by their children’s low interactive behaviors.
· Meaning: The interactive behaviors of children with DDs mediate parenting stress.
- Editorial
- Pulmonology
- Wheezing in infants and preschoolers: phenotypes and treatment options (651 times)
- Jung Yeon Shim
- Clin Exp Pediatr. 2023;66(1):26-27. Published online December 6, 2022
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· Knowing who will develop into asthma or who will not is important to impose proper treatment and early intervention in a child with the first episode of wheezing.
· Phenotypes of severe bronchiolitis in less than 2-year-old children with first episode of wheezing were suggested for different treatment options
· RV-induced and/or atopy-associated severe wheezing in preschool children may benefit from early intervention of asthma treatment.
- Clinical Note
- Endocrinology
- Graves’ disease: an uncommon cause of late sequelae following DRESS (drug reaction with eosinophilia and systemic symptoms) (649 times)
- Therdpong Tempark, Amatanun Tangthanapalakul, Tawatchai Deekajorndech, Susheera Chatproedprai, Vichit Supornsilchai, Siriwan Wananukul
- Clin Exp Pediatr. 2022;65(12):602-604. Published online June 22, 2022
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- Original Article
- Emergency Medicine
- Nonfatal injuries in Korean children and adolescents, 2007–2018 (629 times)
- Gyu Min Yeon, Yoo Rha Hong, Seom Gim Kong
- Clin Exp Pediatr. 2022;65(4):194-200. Published online September 9, 2021
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Question: How many children and adolescents have experienced nonfatal injuries in the previous year?
Finding: Among Korean children and adolescents, 8.1% experienced at least one injury per year. We found no significant change in the incidence of injuries over the previous 12 years.
Meaning: The incidence of injuries is higher than this estimation; therefore, more attention and effort are needed to prevent injuries among children and adolescents.
- Neonatology (Perinatology)
- Mediation effect of cord blood cortisol levels between maternal prepregnancy body mass index and birth weight: a hospital-based cross-sectional study (626 times)
- Nisanth Selvam, Jayashree K, Prasanna Mithra
- Clin Exp Pediatr. 2022;65(10):500-506. Published online July 29, 2022
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Question: What is the association between cord blood cortisol and maternal weight, birth weight, and cord blood lipid profile?
Finding: Cord blood cortisol levels did not influence the relationship between maternal weight changes or birth weight. Maternal weight changes, birth weight, and cortisol levels altered the cord blood lipid profile.
Meaning: Our findings may aid United Nations Sustainable Development Goal 3 (Good Health and Well-Being) achievement by 2030.
- Review Article
- General Pediatrics
- Motor performance of children with attention deficit hyperactivity disorder: focus on the Bruininks-Oseretsky Test of Motor Proficiency (624 times)
- Khushboo Prashant Adhvaryu, Suruliraj Karthikbabu, Pratiksha Tilak Rao
- Clin Exp Pediatr. 2022;65(11):512-520. Published online February 17, 2022
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· Children with attention deficit hyperactivity disorder (ADHD) tend to have impaired motor performance that may affect their growth and development.
· Although widely used among children with developmental disorders, the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) is used sparsely among children with ADHD.
· Assessment by the BOTMP increases our understanding of the motor repertoire of children with ADHD.
· Wider usage of the BOTMP will enable more comprehensive planning of rehabilitation goals to enhance the motor abilities of children with ADHD.
- Editorial
- Neurology
- Lumbar puncture or not: when does febrile seizure require a neurodiagnostic evaluation? (613 times)
- Seung Soo Kim
- Clin Exp Pediatr. 2023;66(2):68-69. Published online December 9, 2022
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· A neurodiagnostic evaluation (lumbar puncture, blood tests, electroencephalography, and neuroimaging) is not indicated in most patients with simple febrile seizures.
· A lumbar puncture is indicated when a central nervous system infection is suspected in any patient with febrile seizures.
· Blood tests (glucose, electrolytes, and complete blood count) are indicated in patients with persistent seizure after benzodiazepine treatment, prolonged loss of consciousness, poor general condition, or signs of dehydration.
- Letter to the Editor
- Developmental and Behavioral Medicine
- The influence of parental eating behaviors, child-feeding practices, and infants’ temperaments upon infants’ eating behaviors (605 times)
- Goh Woon Lim, Kyoung Min Shin
- Clin Exp Pediatr. 2022;65(9):466-468. Published online June 27, 2022
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- Editorial
- Infection
- Impact and role of vitamins as immunonutrition in children during COVID-19 pandemic (605 times)
- Yoo Min Lee
- Clin Exp Pediatr. 2023;66(5):212-214. Published online April 18, 2023
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· Vitamins have effector mechanisms in the innate and adaptive immune systems and potential roles in preventing and reducing the severity of coronavirus disease 2019 (COVID-19).
· Vitamins may be immunonutrients in the treatment of COVID-19 infections and prevention of patient deterioration due to critical illness, thus demonstrating the significance of a nutritious, well-balanced diet.
- Retraction Notice
- Coronavirus disease 2019 in a 2-month-old male infant: a case report from Iran (599 times)
- Hosein Heydari, Seyed Kamal Eshagh Hossaini, Ahmad Hormati, Mahboubeh Afifian, Sajjad Ahmadpour
- Clin Exp Pediatr. 2022;65(8):417-417. Published online July 19, 2022
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- Review Article
- Allergy
- Management of patients with allergic diseases in the era of COVID-19 (577 times)
- Eun Lee
- Clin Exp Pediatr. 2022;65(11):529-535. Published online September 23, 2022
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In the early days of the coronavirus disease 2019 (COVID-19) pandemic, allergic diseases, especially asthma, were considered to be risk factors for severe COVID-19 infection, hospitalization, and death. These concerns stemmed from the idea that individuals with allergic diseases are generally more susceptible to respiratory virus infections, which are major causes of exacerbation of allergic diseases. However, epidemiologic data with...
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