Clinical and Experimental Pediatrics

Original Article

Other

Plastic bottle feeding produces changes in biochemical parameters in human infants – A pilot study (11 times)

Mahendra K. Pant, Abul. H. Ahmad, Manisha Naithani, Jayanti Pant

Clin Exp Pediatr. 2022;65(9):459-465. Published online May 19, 2022

Question: Plastic feeding bottles are used commonly to feed infants who cannot be breastfeed. Does plastic bottle feeding produce biochemical changes in infants?
Finding: The plastic bottles leach out endocrine disruptors and affects bodily functions in terms of biochemical alterations like increased blood urea, raised creatine-kinase–MB levels, and altered lipid profile in infants exposed to bottle feeding.
Meaning: Plastic bottles feeding alters bodily functions in infants.

DOI: https://doi.org/10.3345/cep.2022.00234

Editorial

Pulmonology

Now lung ultrasound has been established as a fundamental examination in pediatric respiratory diseases (11 times)

Kyunghoon Kim

Clin Exp Pediatr. 2022;65(8):401-402. Published online July 13, 2022

· Several studies demonstrated the usefulness of lung ultrasound in pediatric respiratory diseases including coronavirus disease 2019.
· Knowledge of lung ultrasound is increasing, and lung ultrasound has been established as a fundamental diagnostic examination for pediatric respiratory diseases.

DOI: https://doi.org/10.3345/cep.2022.00577

Original Article

Cardiology

Echocardiographic reference z scores of right ventricular dimension and systolic function of children aged 5–12 years (11 times)

Alaba Busola Oladimeji, Moriam Omolola Lamina, Peter Odion Ubuane, Motunrayo Oluwabukola Adekunle, Omolara Adeolu Kehinde, Barakat Adeola Animasahun, Olisamedua FidelisNjokanma

Clin Exp Pediatr. 2023;66(5):215-222. Published online April 18, 2023

Question: Z score reference values for right ventricular size and systolic function in children using echocardiography are available in several countries. Despite the high burden of diseases involving the right ventricle in Nigeria, these reference values have limited applicability.
Finding: The right ventricular sizes of Nigerian children differed from those published elsewhere.
Meaning: These reference values will aid the treatment, monitoring, and pre- and postintervention for Nigerian children.

DOI: https://doi.org/10.3345/cep.2022.01410

Endocrinology

Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis (10 times)

Azam Maleki, Saeid Bashirian, Ali Reza Soltanian, Ensiyeh Jenabi, Abdollah Farhadinasab

Clin Exp Pediatr. 2022;65(2):85-89. Published online April 15, 2021

Web of Science 3 Crossref 5

Question: Have polycystic ovary syndrome (PCOS) increased risk of having an offspring with attention-deficit/hyperactivity disorder (ADHD)?
Finding: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on odds ratio (OR) and relative ratio (RR) (OR, 1.42; 95% confidence interval [CI], 1.27–1.57) and (RR, 1.43; 95% CI, 1.35–1.51), respectively.
Meaning: Our study showed that maternal PCOS is a risk factor for ADHD.

DOI: https://doi.org/10.3345/cep.2021.00178

Review Article

Other

Knowledge-guided artificial intelligence technologies for decoding complex multiomics interactions in cells (10 times)

Dohoon Lee, Sun Kim

Clin Exp Pediatr. 2022;65(5):239-249. Published online November 26, 2021

Web of Science 2 Crossref 2

· The need for data-driven modeling of multiomics interactions was recently highlighted.
· Many artificial intelligence-driven models have been developed, but only a few have incorporated biological domain knowledge within model architectures or training procedures.
· Here we provide a comprehensive review of deep learning models to decipher complex multiomics interactions regarding the biological guidance imposed upon them to facilitate further development of biological knowledge-guided deep learning models.

DOI: https://doi.org/10.3345/cep.2021.01438

Infection

Epidemiological changes in infectious diseases during the coronavirus disease 2019 pandemic in Korea: a systematic review (10 times)

Jong Gyun Ahn

Clin Exp Pediatr. 2022;65(4):167-171. Published online November 30, 2021

Web of Science 10 Crossref 10

· Nonpharmaceutical interventions (NPIs) have had a major impact on the epidemiology of various infectious diseases in Korea.
· Respiratory diseases and gastrointestinal viral diseases were significantly reduced during the NPI period.
· The decrease in Kawasaki disease after the introduction of NPI is an unintended result.
· Infectious diseases that decreased during NPI use may re-emerge.
· We must continuously monitor the epidemiology of various infectious diseases during the coronavirus era

DOI: https://doi.org/10.3345/cep.2021.01515

Neonatology (Perinatology)

Breastfeeding and vitamin D (10 times)

Ju Sun Heo, Young Min Ahn, Ai-Rhan Ellen Kim, Son Moon Shin; for the Korean Society of Breastfeeding Medicine

Clin Exp Pediatr. 2022;65(9):418-429. Published online December 14, 2021

Web of Science 3 Crossref 3

∙ Exclusively breastfed infants are at risk of developing vitamin D deficiency associated with hypocalcemia, rickets, and various health outcomes.
∙ The prevalence of vitamin D deficiency in breastfed infants differs vastly between studies and nations at 0.6%–91.1%.
∙ The vitamin D content of breast milk does not meet the requirements of exclusively breastfed infants.
∙ Most international guidelines recommend that breastfed infants be supplemented with 400 IU/day of vitamin D during the first year of life.
∙ Vitamin D intake (milk+supplements) of 800 IU/day can be considered in preterm infants along with biochemical monitoring.

DOI: https://doi.org/10.3345/cep.2021.00444

Original Article

Gastroenterology

Association between maternal weight gain during pregnancy and child’s body mass index at preschool age (10 times)

Jeewon Shin, Yoowon Kwon, Ju Hee Kim, Su Jin Jeong

Clin Exp Pediatr. 2023;66(2):76-81. Published online November 30, 2022

Question: What are the risk factors of newborn birth weight? Does gestational weight gain and prepregnancy body mass index affect childhood weight?
Finding: Excess maternal weight gain increases the risk of overweight/obesity, newborn birth weight, and child body mass index at 4–6 years.
Meaning: Maternal weight control before and during pregnancy should be well controlled.

DOI: https://doi.org/10.3345/cep.2022.01158

Editorial

Cardiology

Arrhythmias in pediatric patients with COVID-19 (10 times)

Ji-Eun Ban

Clin Exp Pediatr. 2023;66(8):348-349. Published online June 14, 2023

· Childrens with coronavirus disease 2019 less commonly display life-threatening arrhythmias, including premature atrial or ventricular beats, or conduction disturbances such as first-degree atrioventricular blocks.
· Life-threatening arrhythmias (e.g., nonsustained or sustained ventricular tachycardia, atrial tachycardia, atrial fibrillation, complete atrioventricular block) occur in children with sudden acute respiratory syndrome coronavirus-2 infection suffering from myocarditis or multisystem inflammatory syndrome in children (MIS-C).
· Monitoring clinical status and assessing and managing arrhythmias are crucial in MIS-C.

DOI: https://doi.org/10.3345/cep.2023.00584

Original Article

Developmental and Behavioral Medicine

Attention-deficit/hyperactive-impulsive disorder symptoms among grade 1 students with reading disorder in Thailand (10 times)

Patcharapun Sarisuta, Issarapa Chunsuwan, Tippawan Hansakunachai, Paskorn Sritipsukho

Clin Exp Pediatr. 2023;66(11):485-492. Published online October 24, 2023

Question: Would students with reading disorder have a significantly higher prevalence of attention-deficit/hyperactiveimpulsive disorder (ADHD) symptoms than neurotypical students?
Finding: Students at risk of reading disorder exhibited significant ADHD symptoms compared with those not at risk of reading disorder according to all presentations of teacher assessments versus only for predominantly inattentive presentations of the parental assessments.
Meaning: Students with reading disorder have a significantly higher prevalence of ADHD symptoms than neurotypical students. Sex, parental education level, average family income, and children’s school affiliation significantly influenced reading disorder prevalence.

DOI: https://doi.org/10.3345/cep.2023.00773

Emergency Medicine

Nonfatal injuries in Korean children and adolescents, 2007–2018 (9 times)

Gyu Min Yeon, Yoo Rha Hong, Seom Gim Kong

Clin Exp Pediatr. 2022;65(4):194-200. Published online September 9, 2021

Web of Science 1 Crossref 1

Question: How many children and adolescents have experienced nonfatal injuries in the previous year?
Finding: Among Korean children and adolescents, 8.1% experienced at least one injury per year. We found no significant change in the incidence of injuries over the previous 12 years.
Meaning: The incidence of injuries is higher than this estimation; therefore, more attention and effort are needed to prevent injuries among children and adolescents.

DOI: https://doi.org/10.3345/cep.2021.00563

Review Article

Neurology

Recent trends of healthcare information and communication technologies in pediatrics: a systematic review (9 times)

Se young Jung, Keehyuck Lee, Hee Hwang

Clin Exp Pediatr. 2022;65(6):291-299. Published online December 15, 2021

Web of Science 5 Crossref 4

· The innovation of healthcare information communication technology (ICT) was accelerated with the adoption of electronic health records (EHRs).
· Telemedicine currently has no technical barriers.
· EHRs and personal health records are being connected, and mobile/wearable technologies are being integrated into them.
· Conventional rule-based clinical decision support systems have already been implemented and used in EHRs and PHRs. Artificial intelligence/machine learning improves precision and accuracy.

DOI: https://doi.org/10.3345/cep.2020.01333

Correspondence and Reply

Neurobehavior

Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis (9 times)

Hadith Rastad, Mahnaz Seifi Alan

Clin Exp Pediatr. 2022;65(3):152-152. Published online February 17, 2022

DOI: https://doi.org/10.3345/cep.2021.01298.r1

Editorial

Neonatology (Perinatology)

Factors to consider before implementing telemedicine protocols to manage neonatal jaundice (9 times)

Heui Seung Jo

Clin Exp Pediatr. 2022;65(8):403-404. Published online April 12, 2022

In the rapidly changing environmental situation during the coronavirus disease 2019 outbreak, neonatal centers have developed telemedicine systems with extended coverage for neonatal monitoring and high-risk follow-up programs including neonatal hyperbilirubinemia. At this point, electronic health technology and noncontact medical system increase the effectiveness of rather than replacing the face-to-face visit and the opinions of experienced neonatologists.

DOI: https://doi.org/10.3345/cep.2022.00227

Endocrinology

Low bone mineral density can occur in children after shortterm systemic glucocorticoid treatment (9 times)

Moon Bae Ahn

Clin Exp Pediatr. 2022;65(6):300-301. Published online April 27, 2022

Osteoporosis diagnosed in children with chronic diseases is a major endocrine complication triggered by the disease itself or its treatment. Although age upon starting osteotoxic agents and the their duration of use are vital contributors, spontaneous recovery of bone mass following treatment completion is a privilege of this specific age group. For any patients short-term glucocorticoid therapy, bone health screening is the next step.

DOI: https://doi.org/10.3345/cep.2021.01599

Original Article

Hematology

Effect of cyclic pamidronate administration on osteoporosis in children with β-thalassemia major: a single-center study (9 times)

Mahmoud A. El-Hawy, Nagwan Y. Saleh

Clin Exp Pediatr. 2022;65(8):405-409. Published online June 7, 2022

Web of Science 1 Crossref 1

Question: What is the effect of cyclic pamidronate administration on osteoporosis in children with β-thalassemia major?
Finding: The dual-energy x-ray absorptiometry scan findings of children with β-thalassemia major and osteoporosis were improved after pamidronate administration.
Meaning: Cyclic pamidronate effectively treated osteoporosis in children with β-thalassemia major.

DOI: https://doi.org/10.3345/cep.2019.00535

Letter to the Editor

Cardiology

Early prophylaxis of cardiomyopathy with beta-blockers and angiotensin receptor blockers in patients with Duchenne muscular dystrophy (9 times)

Heirim Lee, Jinyoung Song, I-Seok Kang, June Huh, Jin A Yoon, Yong Beom Shin

Clin Exp Pediatr. 2022;65(10):507-509. Published online August 22, 2022

Web of Science 2 Crossref 2

DOI: https://doi.org/10.3345/cep.2022.00836

Infection

Chest x-ray findings in children with COVID-19: lesson learned from referral hospitals in Medan, North Sumatera, Indonesia (9 times)

Andrew Limavady, Eka Airlangga, Ririe Fachrina Malisie, Ayodhia Pitaloka Pasaribu

Clin Exp Pediatr. 2023;66(7):317-319. Published online May 16, 2023

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/cep.2022.01179

Editorial

Gastroenterology

Is there a link between social media usage and functional gastrointestinal disorders in children? (9 times)

Hae Jeong Lee

Clin Exp Pediatr. 2023;66(4):169-170. Published online March 23, 2023

Social media use has potential benefits and risks, including links to adverse health problems in children such as functional gastrointestinal disorders (FGIDs). Screen time control, emotional support, and parental guidance can help children navigate social media safely and reduce the risk of developing FGIDs.

DOI: https://doi.org/10.3345/cep.2023.00143

Correspondence

Cardiology

The authors reply: Age-, sex-, and height-based blood pressure reference charts, Yazd children 6–18 years, Iran (9 times)

Seyedeh Mahdieh Namayandeh, Nastran Ahmadi, Seyed Mahmood Sadr

Clin Exp Pediatr. 2023;66(9):414-414. Published online June 14, 2023

DOI: https://doi.org/10.3345/cep.2021.01312

Letter to the Editor

Infection

SARS-CoV-2 fecal shedding pattern in pediatric patients with acute COVID-19 or COVID-19-associated multisystem inflammatory syndrome (9 times)

Setareh Mamishi, Fatemeh Jalali, Sepideh Benvari, Babak Pourakbari, Mohammad Reza Abdolsalehi, Reihaneh Hosseinpour Sadeghi, Mohammad Shahbabaie, Amene Navaeian, Shima Mahmoudi

Clin Exp Pediatr. 2023;66(8):366-368. Published online June 14, 2023

DOI: https://doi.org/10.3345/cep.2023.00297

Correspondence

General Pediatrics

Letter to the editor: Age-, sex-, and height-based blood pressure reference charts, Yazd children 6-18 years, Iran (8 times)

Amar Taksande

Clin Exp Pediatr. 2023;66(9):412-413. Published online October 27, 2021

DOI: https://doi.org/10.3345/cep.2020.02103

Original Article

Neonatology (Perinatology)

Mediation effect of cord blood cortisol levels between maternal prepregnancy body mass index and birth weight: a hospital-based cross-sectional study (8 times)

Nisanth Selvam, Jayashree K, Prasanna Mithra

Clin Exp Pediatr. 2022;65(10):500-506. Published online July 29, 2022

Web of Science 1 Crossref 1

Question: What is the association between cord blood cortisol and maternal weight, birth weight, and cord blood lipid profile?
Finding: Cord blood cortisol levels did not influence the relationship between maternal weight changes or birth weight. Maternal weight changes, birth weight, and cortisol levels altered the cord blood lipid profile.
Meaning: Our findings may aid United Nations Sustainable Development Goal 3 (Good Health and Well-Being) achievement by 2030.

DOI: https://doi.org/10.3345/cep.2022.00122

Neurobehavior

Association between previous abortion history and risk of autism spectrum disorders among offspring: a meta-analysis (8 times)

Ensiyeh Jenabi, Erfan Ayubi, Saeid Bashirian, Mahdieh Seyedi, Mohammad Rezaei

Clin Exp Pediatr. 2023;66(2):70-75. Published online August 17, 2022

Web of Science 2 Crossref 2

Question: This study aimed to determine whether there is an association between previous abortion history and the risk of autism spectrum disorders (ASDs) among children.
Finding: We found that the risk of ASD associated with previous abortion history had an odds ratio of 1.64 (95% confidence interval, 1.28–2.0; I²=61.7%).
Meaning: These findings suggest a positive and significant association between history of previous abortion and risk of ASD in children.

DOI: https://doi.org/10.3345/cep.2022.00108

Perspective

Infection

Statement on healthcare system preparedness in response to COVID-19 Omicron subvariants BA.4 and BA.5 surge in Korea from the Korean Pediatric Society and Korean Society of Pediatric Infectious Diseases (8 times)

Eun Young Cho, Dong Hyun Kim, Soo-Han Choi, Ki Wook Yun, Jong Gyun Ahn, Hye-Kyung Cho, Hyunju Lee, Jina Lee, Taek-Jin Lee, Byung-Wook Eun, Jin Lee, Dae Sun Jo, Yun-Kyung Kim, Yae-Jean Kim; Committee on Infectious Diseases of the Korean Pediatric Society

Clin Exp Pediatr. 2022;65(11):510-511. Published online September 23, 2022

Web of Science 2 Crossref 2

In order to respond to the recent surge in coronavirus disease 2019 (COVID-19) cases and the continuously changing epidemiology of COVID-19, a sustainable and flexible pediatric healthcare system must be prepared considering the specificity of pediatric care. We demand a more proactive response from the health authorities to check the current state of pediatric COVID-19 patient care and to ensure that pediatric patients receive appropriate and timely management.

DOI: https://doi.org/10.3345/cep.2022.01088

Clinical Note

Other

Novel PTRH2 gene variant causing IMNEPD (infantile-onset multisystem neurologic, endocrine, and pancreatic disease) in 2 Saudi siblings (8 times)

Dalal K. Bubshait

Clin Exp Pediatr. 2023;66(5):223-225. Published online March 23, 2023

DOI: https://doi.org/10.3345/cep.2022.01074

Editorial

Other

Advancing pediatric health: the multifaceted scope of Clinical and Experimental Pediatrics (8 times)

Jin Hee Oh, Man Yong Han

Clin Exp Pediatr. 2023;66(4):171-172. Published online March 29, 2023

Clinical and Experimental Pediatrics (CEP) is a journal that specializes in pediatric research topics. It covers a wide range of research areas, including basic research, translational research, and research related to improving pediatric health and diseases. CEP also focuses on the coordination of societal structures and processes that orchestrate pediatric health and disease throughout society, and the parallel relationship between regional characteristics and globalization. The journal intends to continue promoting pediatric health through relentless efforts and the discovery of new research areas.

DOI: https://doi.org/10.3345/cep.2023.00185

Neurology

Understanding the usefulness of electroencephalography source localization (8 times)

Bo Lyun Lee

Clin Exp Pediatr. 2023;66(5):210-211. Published online April 18, 2023

· Electroencephalography (EEG) records brain activity with high temporal resolution.
· EEG source localization, combined with other functional or structural imaging methods, provides information about brain network and connectivity in clinical neuroscience.
· EEG source localization identifies brain location from electrical current sources in several neuropsychiatric diseases such as epilepsy, attention deficit/hyperactivity disorder, and anxiety disorders.

DOI: https://doi.org/10.3345/cep.2022.01480

Review Article

Neonatology (Perinatology)

Growth patterns of preterm infants in Korea (7 times)

Joohee Lim, So Jin Yoon, Soon Min Lee

Clin Exp Pediatr. 2022;65(1):1-9. Published online July 8, 2021

Web of Science 1 Crossref 1

∙ The growth of preterm infants is a main focus of neonatology.
∙ Preterm infants in Korea, especially those with a very low birth weight, achieve retarded growth.
∙ Careful growth monitoring and early intervention will contribute to better development outcomes and quality of life for preterm infants and improve public health.

DOI: https://doi.org/10.3345/cep.2021.00234

Original Article

Neonatology (Perinatology)

Is fetal nuchal cord associated with autism spectrum disorder? A meta-analysis (7 times)

Ensiyeh Jenabi, Maryam Ahmadi, Azam Maleki

Clin Exp Pediatr. 2022;65(3):131-135. Published online September 24, 2021

Question: Is fetal nuchal cord a risk factor for autism spectrum disorder (ASD)?
Finding: Five articles (1 cohort, 4 case-control; total 3,088 children) were included in the present meta-analysis. Fetal nuchal cord was not a risk factor for ASD (odds ratio, 1.11; 95% confidence interval, 0.66–1.57). There was homogeneity among studies that reported a risk of ASD (I²=0.0).
Meaning: Fetal nuchal cord is not a risk factor for ASD.

DOI: https://doi.org/10.3345/cep.2021.00514

Cited By 22	Retinopathy of prematurity: a review of epidemiology and current treatment strategies
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Cited By 18	Global relationship between parent and child obesity: a systematic review and meta-analysis
Cited By 14	Gross motor dysfunction and balance impairments in children and adolescents with Down syndrome: a systematic review
Cited By 13	Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease

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