| An Experimental Study on The Influence of The Cerebral Cortex upon Urinary Output |
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Jong Man Lee |
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Dept, of Pediatrics, College of Medicine, Seoul National University |
| 大腦皮質에 있어 尿量에 影響을 미치는 部位에 關한 實驗的硏究 |
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李 鍾 萬 |
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서울大學校 醫科大學 小兒科學敎室 |
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| Abstract |
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Many studies have been reported on the role of hypothalamus as the regulating center of the water and electrolyte balances also, there have been many experimental assertions on direct connections of nerve
fibers between hypothalamus and cerebral cortex. Author experimentally observed the changes of the urinary output by the osmotic stimulation on the 23 areas of cerebral cortex which author divided. Korean white male rabbits weighing 1.8 kg. were used as experimental animals, and 2% sodium chloride solution administered per os for 3 times by 1 hour interval before osmotic stimulation. The amount of sodium chloride solution administered corresponds to of individual body weight. The osmotic stimulation on the cerebral cortex with 2% hypertonic sodium chloride solution was followed and the measurement on the urine was made by 5 min. interval. The following findings were observed. 1.A rapid and marked reduction of urine output was observed in 7 rabbits by the osmotic stimulation with 2% hypertonic sodium chloride solution on the “a” area. 2.A rapid and marked reduction of urine output was observed in 7 rabbits by the osmotic stimulation with 2% hypertonic sodium chloride solution on the “I” area. 3.A rapid and marked reduction of urine output was also observed in 7 rabbits by the osmotic stimulation with 2% hypertonic sodium chloride solution on the “x” area. 4.No remarkable changes in the urine output were observed by the osmotic stimulation on the other 20 areas of cerebral cortex. Above mentioned experimental findings lead us to such conclusion that possible connections exist between hypothalamus and a, 1 and x area of cerebral cortex and these areas might be correspond to
the cingulate gyrus, the anterior parts of the temporal lobe and the orbito-frontal area respectively. In addition these areas are considered to be related with the action of osmoreceptor either directly or indirectly. |
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