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Most-cited articles are from the articles published during the last two years (2022 ~ ).
- Review Article
- Allergy
- Diagnosis and management of asthma in infants and preschoolers
- Hai Lee Chung
- Clin Exp Pediatr. 2022;65(12):574-584. Published online April 19, 2022
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· Asthma in infants and preschoolers involves heterogeneous phenotypes.
· Asthma diagnosis is based on symptom patterns, therapeutic responses, and the presence of risk factors with careful consideration of differential diagnosis.
· Daily inhaled corticosteroid therapy remains the most effective strategy for managing persistent asthma symptoms irrespective of phenotype.
· Future research, including genetic and molecular studies, is needed to develop a clear definition of asthma and personalized therapeutic approaches.
- Editorial
- Endocrinology
- Pediatric obesity: life cycle approach of pediatrician and society
- Yong Hee Hong
- Clin Exp Pediatr. 2022;65(1):29-30. Published online December 28, 2021
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• With the emerging epidemic of pediatric obesity, many endocrine comorbidities classically seen in adulthood are surfacing much earlier in life.
• Appropriate obesity counseling and education should be provided from infancy to adolescence.
• Managing pediatric obesity may require school and society involvement.
- Review Article
- Other
- Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy
- Lisa Zhao, John P. Jones, Lauren G. Anderson, Zacharoula Konsoula, Cynthia D. Nevison, Kathryn J. Reissner, William Parker
- Clin Exp Pediatr. 2024;67(3):126-139. Published online June 14, 2023
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Despite worldwide acceptance of acetaminophen (paracetamol) in pediatric medicine, careful examination reveals no valid objections to the conclusion that early exposure to acetaminophen causes neurodevelopmental injury in susceptible babies and children. Nevertheless, debate that early exposure to acetaminophen causes neurodevelopmental injury has centered around the prenatal period, evidence of which is relatively limited compared to that in the postnatal period, which is the time of greatest absolute and relative risk.
- Original Article
- Neonatology (Perinatology)
- Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: a systematic review and meta-analysis
- Asha P. Shetty, Kurvatteppa Halemani, Alwin Issac, Latha Thimmappa, Sanjay Dhiraaj, Radha K, Prabhaker Mishra, Vijai Datta Upadhyaya
- Clin Exp Pediatr. 2024;67(2):104-115. Published online November 14, 2023
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Question: What emotions do parents experience when their newborns are admitted to the neonatal intensive care unit (NICU)?
Finding: Mothers experienced more anxiety (51%), depression (31%), and stress (41%) symptoms than fathers (26%, 12%, and 22%, respectively).
Meaning: Parents often experience anxiety, stress, and depression following NICU admission. Healthcare workers are responsible for providing regular parental counseling.
- Review Article
- Gastroenterology
- Prevalence, risk factors, and treatment of small intestinal bacterial overgrowth in children
- Yu Kyung Cho, Jin Lee, Chang Nyol Paik
- Clin Exp Pediatr. 2023;66(9):377-383. Published online August 21, 2023
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· Pediatric small intestinal bacterial overgrowth (SIBO) manifestations range from nonspecific abdominal symptoms to malabsorption or malnutrition.
· SIBO is prevalent in children and adolescents with functional abdominal pain disorders.
· Predisposing factors include disturbed intestinal motility, altered anatomy, and/or abnormal body defense systems against intestinal bacteria.
· Breath tests are safe and noninvasive.
· Treatment principles include managing predisposing conditions, nutritional support, symptom control, and antibiotics.
- Neonatology (Perinatology)
- Neurodevelopmental outcomes of preterm infants
- In Gyu Song
- Clin Exp Pediatr. 2023;66(7):281-287. Published online December 30, 2022
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· Among survivors, 60.9% of infants born at 22 weeks’ gestation had moderate to severe impairments, whereas 50.3% born at 23 weeks’ and 42.2% at 24 weeks’ gestation had moderate to severe impairments.
· Moderate and late preterm infants reportedly have less severe disease than very preterm infants, but they still experience adverse neurodevelopmental outcomes.
· The careful follow-up and early detection of developmental problems in these patients are required.
- Gastroenterology
- Liver fibrosis in children: a comprehensive review of mechanisms, diagnosis, and therapy
- Elif Ozdogan, Cigdem Arikan
- Clin Exp Pediatr. 2023;66(3):110-124. Published online December 19, 2022
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· Chronic liver diseases in children are heterogenous but converge in the common pathway of fibrosis.
· Much of the literature on mechanisms of fibrogenesis focus on adults but pediatric physiology has documented differences.
· Understanding of these distinctions are necessary to define, treat, and prevent fibrosis.
· Current management of liver fibrosis relies heavily on liver biopsy. Multiple tools have shown high diagnostic performance in pediatric and adult populations. Large, multicenter studies are needed for validation.
- Original Article
- Neurobehavior
- Association between previous abortion history and risk of autism spectrum disorders among offspring: a meta-analysis
- Ensiyeh Jenabi, Erfan Ayubi, Saeid Bashirian, Mahdieh Seyedi, Mohammad Rezaei
- Clin Exp Pediatr. 2023;66(2):70-75. Published online August 17, 2022
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Question: This study aimed to determine whether there is an association between previous abortion history and the risk of autism spectrum disorders (ASDs) among children.
Finding: We found that the risk of ASD associated with previous abortion history had an odds ratio of 1.64 (95% confidence interval, 1.28–2.0; I2=61.7%).
Meaning: These findings suggest a positive and significant association between history of previous abortion and risk of ASD in children.
- Review Article
- Infection
- Pathogenetic and etiologic considerations of febrile seizures
- Ji Yoon Han, Seung Beom Han
- Clin Exp Pediatr. 2023;66(2):46-53. Published online January 13, 2023
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· Inflammatory responses accompanying fever increase neuronal excitability in the central nervous system, which in turn provokes seizures.
· Fever in children with febrile seizures is usually caused by common respiratory viruses, the distributions of which match those of seasonal community-acquired respiratory tract infections.
· Several genetic variations in ion channels seem associated with neuronal hyperexcitability in children with febrile seizures.
- Original Article
- Gastroenterology
- Inferior vena cava to aorta ratio in dehydrated pediatric patients: a systematic review and meta-analysis
- Gilbert Sterling Octavius, Michelle Imanuelly, Johan Wibowo, Nadia Khoirunnisa Heryadi, Melanie Widjaja
- Clin Exp Pediatr. 2023;66(11):477-484. Published online June 14, 2023
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Question: The inferior vena cava to aorta (IVC/Ao) ratio measured via ultrasound has been touted as a promising noninvasive technique to assess clinically significant dehydration in pediatric patients.
Finding: Our meta-analysis found that IVC/Ao ratio had a positive likelihood ratio of 3.2 (95% confidence interval [CI], 2.1–5.1) and negative likelihood ratio of 0.18 (95% CI, 0.12–0.28).
Meaning: Hence, IVC/Ao ratio is insufficient to exclude or confirm significant dehydration in pediatric patients.
- Review Article
- Nephrology (Genitourinary)
- Kidney complications associated with COVID-19 infection and vaccination in children and adolescents: a brief review
- Hee Sun Baek, Min Hyun Cho
- Clin Exp Pediatr. 2023;66(10):424-431. Published online June 28, 2023
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Several observational studies have shown that acute kidney injury affects up to 46% of children and adolescents who develop severe postinflammatory responses, such as multisystem inflammatory syndrome in childhood, due to coronavirus disease 2019 (COVID-19). Although causality has not been established, some cases of glomerulopathy or nephrotic syndrome occurring after COVID-19 infection or vaccination have been reported. Therefore, kidney complications associated with these conditions in children and adolescents warrant attention.
- Cardiology
- Research trends on causes of Kawasaki disease in the COVID-19 era: focus on viral infections
- Young Hwan Lee
- Clin Exp Pediatr. 2023;66(1):1-11. Published online June 22, 2022
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· The etiology of Kawasaki disease (KD) is unclear, but its clinical, epidemiological, and pathophysiological characteristics are strongly associated with infectious diseases.
· In the coronavirus disease 2019 pandemic era, viruses are attracting the most attention. Sudden acute respiratory syndrome coronavirus 2 infection causes various hyperinflammation in children that require differentiation from KD.
· Immune responses in patients with KD may be induced by host cell damage. To effectively prevent and treat KD, the genetic background and immune responses of KD patients and triggering pathogens require identification.
- Gastroenterology
- Current diagnosis and image-guided reduction for intussusception in children
- Jisun Hwang, Hee Mang Yoon, Pyeong Hwa Kim, Ah Young Jung, Jin Seong Lee, Young Ah Cho
- Clin Exp Pediatr. 2023;66(1):12-21. Published online July 4, 2022
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· Intussusception, the most common cause of small bowel obstruction in young children, has an overall incidence in Korea of 28.3 cases per 100,000 person-years.
· Its cause is idiopathic inmost cases, although viral or bacterial gastroenteritis has beenpostulated as a cause. Approximately 4% of children have pathological lead points for intussusception, and Meckel’s diverticulum is the most common cause.
· Intussusception in preterm infants is extremely rare. Older children (>5 years of age) are at increased risk of pathological lead points.
- Editorial
- Pulmonology
- Community-acquired pneumonia in Korean children: time to read between the lines
- Dong In Suh
- Clin Exp Pediatr. 2023;66(1):22-23. Published online November 10, 2022
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· Various studies have reported the etiology of community-acquired pneumonia (CAP) in Korean children
· Factors other than etiology are equally important to a compre hensive understanding of CAP
· Knowledge from archived reports is no longer directly applicable to the current CAP and requires careful modification
- Original Article
- Neurology
- Long-term neurological cognitive, behavioral, functional, and quality of life outcomes after fetal myelomeningocele closure: a systematic review
- Andre Marolop Pangihutan Siahaan, Martin Susanto, Sarma Nursani Lumbanraja, Dwi Herawati Ritonga
- Clin Exp Pediatr. 2023;66(1):38-45. Published online November 30, 2022
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· Fetal myelomeningocele closure significantly improved long-term neurological cognitive, behavioral, functional, and quality of life outcomes, most likely by reducing hydrocephalus rates.
· However, fetal myelomeningocele closure is associated with a significant risk of pregnancy complications, especially premature rupture of membranes and preterm delivery.
- Cardiology
- Early myocardial functional abnormalities in primary dyslipidemia: clinical and echocardiographic observations in young children from a highly consanguineous population
- Nehal M. El-koofy, Aya M. Fattouh, Areef Ramadan, Mohamed A. Elmonem, Dina H. Hamed
- Clin Exp Pediatr. 2022;65(8):410-416. Published online December 8, 2021
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In children with primary dyslipidemia, functional myocardial abnormalities can occur at young age, including diastolic functional impairment of both ventricles and narrowing of the aortic valve and the sinus of Valsalva. Echocardiographic evaluations of high-risk children may be as important as biochemical evaluations.
- Review Article
- Gastroenterology
- Clinical importance of immunonutrition in infants: a review of the recent literature
- Ji Sook Park
- Clin Exp Pediatr. 2022;65(7):337-343. Published online February 17, 2022
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Nutrients are important in the developing immune system. Human milk supplies diverse bioactives to prevent acute infection or chronic inflammation. Immunoglobulins, lactoferrin, and glutamine in human milk decrease gastrointestinal and respiratory infection. Human milk oligosaccharides promote the growth of intestinal microbiota, the gut barrier, and antimicrobial or antiviral activity. Micronutrients act as anti-inflammatory immunonutrients, too. However, the toxicity of some nutrients from an overdose should be considered.
- Editorial
- Nutrition
- Human milk oligosaccharides as immunonutrition key in early life
- Jung Ok Shim
- Clin Exp Pediatr. 2022;65(7):344-345. Published online May 3, 2022
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· Human milk is a major source of immunonutrients for neonates and infants. Human milk oligosaccharides (HMOs) act as prebiotics and promote the growth of commensal bacteria.
· HMOs inhibit microorganism adhesion to the gut mucosa through interactions with the commensal microbiome and improve gut barrier function by increasing short-chain fatty acid mediated by bifidobacteria and immunomodulation.
· Several randomized controlled trials recently reported on HMOs.
- Original Article
- Infection
- Role of lung ultrasound patterns in monitoring coronavirus disease 2019 pneumonia and acute respiratory distress syndrome in children
- Satyabrata Roychowdhoury, Subhajit Bhakta, Manas Kumar Mahapatra, Saptarshi Ghosh, Sayantika Saha, Mithun Chandra Konar, Mihir Sarkar, Mousumi Nandi
- Clin Exp Pediatr. 2022;65(7):358-366. Published online May 13, 2022
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Question: Potential role of patterns of lung ultrasonography (US) in monitoring changes in mechanically ventilated patients with coronavirus disease 2019 (COVID-19) pneumonia.
Finding: Interstitial syndrome, an irregular pleural line, and peripheral microconsolidation were the most prevalent findings. Changes in lung aeration after mechanical ventilation corelated with improved oxygenation. A fall in lung ultrasound reaeration score ≤ 5 may predict successful weaning.
Meaning: Lung US is gaining wider utility for monitoring COVID-19 pneumonia.
- General Pediatrics
- Effect of 2–6 weeks of systemic steroids on bone mineral density in children
- Athira Kuniyil, Somdipa Pal, Namrita Sachdev, Tribhuvan Pal Yadav
- Clin Exp Pediatr. 2022;65(5):254-261. Published online November 18, 2021
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Question: Does steroid use for 2–6 weeks in children affect bone mineral content (BMC) or density (BMD)?
Finding: Steroid use for 2–6 weeks significantly decreased BMC and BMD of the whole body, total body less the head, lumbar spine, and distal radius. A significant negative correlation was observed among BMD, duration, and cumulative dose.
Meaning: Steroid use for 2–6 weeks in children negatively affected BMC and BMD.
- Review Article
- Other
- Knowledge-guided artificial intelligence technologies for decoding complex multiomics interactions in cells
- Dohoon Lee, Sun Kim
- Clin Exp Pediatr. 2022;65(5):239-249. Published online November 26, 2021
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· The need for data-driven modeling of multiomics interactions was recently highlighted.
· Many artificial intelligence-driven models have been developed, but only a few have incorporated biological domain knowledge within model architectures or training procedures.
· Here we provide a comprehensive review of deep learning models to decipher complex multiomics interactions regarding the biological guidance imposed upon them to facilitate further development of biological knowledge-guided deep learning models.
- Neonatology (Perinatology)
- Pathophysiology, classification, and complications of common asymptomatic thrombocytosis in newborn infants
- Ga Won Jeon
- Clin Exp Pediatr. 2022;65(4):182-187. Published online October 18, 2021
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· Thrombocytosis, common in newborns and infants (<2 years) (3%–13%), is caused by elevated thrombopoietin (TPO) concentrations.
· Serum TPO levels are significantly higher immediately to 1 month postnatal and decrease with age.
· Platelet counts are positively correlated with gestational age at birth and postnatal age.
· Thrombocytosis is more common in preterm than in term infants.
· Thrombocytosis in newborns is reactive and resolves spontaneously without complications.
- Editorial
- Endocrinology
- Clinical and diagnostic importance of dyslipidemia in children and adolescents during the coronavirus disease 2019 pandemic
- Eun Young Kim
- Clin Exp Pediatr. 2022;65(3):129-130. Published online January 14, 2022
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∙ Because childhood lipid concentrations continue into adulthood, early evaluation and treatment are needed, but dyslipidemia awareness is low.
∙ For the prevention and treatment of dyslipidemia in childhood and adolescence, a major risk factor for cardiovascular disease in adulthood, lifestyle modifications, appropriate exercise, and drug treatment are required.
∙ A large-scale study of the prevalence and therapeutic effects of dyslipidemia in children and adolescents in Korea is needed.
- Clinical Note
- Endocrinology
- Graves’ disease: an uncommon cause of late sequelae following DRESS (drug reaction with eosinophilia and systemic symptoms)
- Therdpong Tempark, Amatanun Tangthanapalakul, Tawatchai Deekajorndech, Susheera Chatproedprai, Vichit Supornsilchai, Siriwan Wananukul
- Clin Exp Pediatr. 2022;65(12):602-604. Published online June 22, 2022
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- Review Article
- Neonatology (Perinatology)
- Neonatal seizures: stepping outside the comfort zone
- Menna Hashish, Mohamed Reda Bassiouny
- Clin Exp Pediatr. 2022;65(11):521-528. Published online April 4, 2022
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· Use conventional and amplitude-integrated electroencephalography to confirm clinical seizures and screen high-risk newborns.
· Select an explicit clear elective event to be treated with less toxic and more effective antiepileptics.
- Perspective
- Infection
- Statement on healthcare system preparedness in response to COVID-19 Omicron subvariants BA.4 and BA.5 surge in Korea from the Korean Pediatric Society and Korean Society of Pediatric Infectious Diseases
- Eun Young Cho, Dong Hyun Kim, Soo-Han Choi, Ki Wook Yun, Jong Gyun Ahn, Hye-Kyung Cho, Hyunju Lee, Jina Lee, Taek-Jin Lee, Byung-Wook Eun, Jin Lee, Dae Sun Jo, Yun-Kyung Kim, Yae-Jean Kim; Committee on Infectious Diseases of the Korean Pediatric Society
- Clin Exp Pediatr. 2022;65(11):510-511. Published online September 23, 2022
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In order to respond to the recent surge in coronavirus disease 2019 (COVID-19) cases and the continuously changing epidemiology of COVID-19, a sustainable and flexible pediatric healthcare system must be prepared considering the specificity of pediatric care. We demand a more proactive response from the health authorities to check the current state of pediatric COVID-19 patient care and to ensure that pediatric patients receive appropriate and timely management.
- Original Article
- Gastroenterology
- Probiotics added to maternal nutrition affect ınfantile colic symptoms and fecal microbiota profile: a single-blind randomized controlled study
- Aysu Yıldız Karaahmet, Gülümser Dolgun, Metehan Özen
- Clin Exp Pediatr. 2022;65(11):547-554. Published online September 23, 2022
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Question: Do probiotics added to maternal nutrition affect infantile colic symptoms and intestinal microbiota?
Finding: Infants whose mothers ingested probiotics demonstrated decreased crying frequency and intensity and significantly increased bacterial diversity in the stools. The bacterial variety was substantially affected by the added probiotic product.
Meaning: The addition of probiotics to maternal nutrition in early infancy could play an important role in preventing infantile colic.
- Editorial
- Nephrology (Genitourinary)
- Hypertension in adulthood is programmed during the perinatal period
- Min Hyun Cho
- Clin Exp Pediatr. 2022;65(10):494-495. Published online August 12, 2022
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∙ Intrauterine growth restriction (IUGR) and preterm birth can be significant risk factors for the development of adult hypertension.
∙ Several perinatal factors of hypertension are related to IUGR, including renal, vascular, and rapid catch-up growth.
- Letter to the Editor
- Cardiology
- Early prophylaxis of cardiomyopathy with beta-blockers and angiotensin receptor blockers in patients with Duchenne muscular dystrophy
- Heirim Lee, Jinyoung Song, I-Seok Kang, June Huh, Jin A Yoon, Yong Beom Shin
- Clin Exp Pediatr. 2022;65(10):507-509. Published online August 22, 2022
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- Review Article
- Gastroenterology
- Upper gastrointestinal tract involvement of Crohn disease: clinical implications in children and adolescents
- Eun Sil Kim, Mi Jin Kim
- Clin Exp Pediatr. 2022;65(1):21-28. Published online September 10, 2021
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· Clinical manifestations of upper gastrointestinal (UGI) tract involvement in Crohn's disease (CD) are common but often clinically underestimated.
· Diagnosing CD by confirming inflammation of the UGI tract histologically is challenging because macroscopic and microscopic findings overlap with those of other diseases.
· Ongoing efforts are needed to enable a standardized assessment of UGI CD in the future.
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
