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Review article

Quantifying myelin in neonates using magnetic resonance imaging: a systematic literature review

Nabila Hanem Arshad^1,2  , Hasyma Abu Hassan¹  , Nur Farhayu Omar¹  , Zurina Zainudin³ 

¹Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Persiaran Universiti 1, 43400 Serdang, Selangor, Malaysia
²Department of Radiology, Hospital Sultan Abdul Aziz Shah, Universiti Putra Malaysia, Persiaran UPM-MARDI, 43400 Serdang, Selangor, Malaysia
³Department of Paediatrics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Persiaran Universiti 1, 43400 Serdang, Selangor, Malaysia

Correspondence Nabila Hanem Arshad ,Email: hanem@upm.edu.my

Received: March 29, 2023; Revised: August 11, 2023   Accepted: August 12, 2023.

Abstract

This review aimed to assess the usefulness of various magnetic resonance imaging (MRI) techniques for the quantification of neonatal white matter myelination. The Scopus, PubMed, and Web of Science databases were searched to identify studies following the PRISMA (preferred reporting items for systematic reviews and meta-analyses) statement using quantitative MRI techniques to examine samples collected from neonates to quantify myelin. Twelve studies were ultimately included. The results demonstrated that in validation studies, relaxometry is the most frequently explored approach (83.33%), followed by magnetization transfer imaging (8.33%) and a new automatic segmentation technique (8.33%). Synthetic MRI is recommended for quantifying myelin in neonates because of several advantages that outweigh a few negligible limitations.

Keywords :Brain, Magnetic resonance imaging, Myelin, Neonate, Quantitative